ArticleScientific reports2013
A non-invasive imaging for the in vivo tracking of high-speed vesicle transport in mouse neutrophils.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effects of Kinesio taping on skin deformation during knee flexion and extension: a preliminary study.BMC musculoskeletal disorders · 2022Article
- Intracellular transport dynamics revealed by single-particle tracking.Biophysics reports · 2021Article
- Article
- Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils.Frontiers in immunology · 2018Review
- Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells.Biophysical journal · 2017Article
- Imaging of anticancer drug action in single cells.Nature reviews. Cancer · 2017Review
- Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.Advanced drug delivery reviews · 2017Review
- Inducing Ischemia-reperfusion Injury in the Mouse Ear Skin for Intravital Multiphoton Imaging of Immune Responses.Journal of visualized experiments : JoVE · 2016Article
- Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice.Journal of visualized experiments : JoVE · 2016Article
- Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons.Alcoholism, clinical and experimental research · 2015Article
- On the Computing Potential of Intracellular Vesicles.PloS one · 2015Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils play an essential role in the innate immune response. To understand neutrophil activity, the development of a new technique to observe neutrophils in situ is required. Here, we report the development of a non-invasive technique for the in vivo imaging of neutrophils labeled with quantum dots, up to 100 μm below the skin surface of mice. Upon inflammation neutrophils began to extravasate from blood vessels and locomoted in interstitial space. Most intriguingly, the quantum dots were endocytosed into vesicles in the neutrophils, allowing us to track the vesicles at 12.5 msec/frame with 15-24 nm accuracy. The vesicles containing quantum dots moved as "diffuse-and-go" manner and were transported at higher speed than the in vitro velocity of a molecular motor such as kinesin or dynein. This is the first report in which non-invasive techniques have been used to visualize the internal dynamics of neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.