ReviewDevelopmental and comparative immunology2014
The Drosophila IMD pathway in the activation of the humoral immune response.
Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers.
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Who cites it
179 citing papers in PubMed.
- Transcriptomic analysis reveals members and expression characteristics of innate immunity genes in Chinese scorpion Mesobuthus martensii.Scientific reports · 2026Article
- BmADARa cooperatively inhibits BmNPV proliferation through the interaction of its dsRBD2 with BmDcr-2-DEXHc in silkworm, Bombyx mori.Insect science · 2026Article
- Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis.Disease models & mechanisms · 2026Article
- Pre-Emptive Upregulation of Antimicrobial Peptides by Dietary Propolis Improves Ethanol Tolerance inInsects · 2026Article
- Insect immunity unveiled: exploring the molecular and cellular defenses against microbial threats.Archives of microbiology · 2026Review
- A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine.Nature communications · 2026Article
- Heterogeneous NF-κB activation and enhancer features shape transcription in Drosophila immunity.Biophysical journal · 2026Article
- Shielded by the dead: how killed bacteria shape the dynamics and evolution of innate immunity.bioRxiv : the preprint server for biology · 2026Article
- Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body.PLoS genetics · 2026Article
- The symbiotic Wolbachia in Anopheles and its role in reducing the transmission of Plasmodium: updates and prospects.Archives of microbiology · 2026Review
- Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026Article
- Article
- Spatial microenvironments tune immune response dynamics in thebioRxiv : the preprint server for biology · 2025Article
- A PGRPLC1/Rel2-F axis controls Anopheles gambiae resistance to systemic infections with Gram-positive bacteria containing Lys-type peptidoglycan.PLoS pathogens · 2025Article
- Functionality of highly diverged Imd like genes identified in stinkbugs and bedbugs.Scientific reports · 2025Article
- Heterogeneous NF-κB activation and enhancer features shape transcription inbioRxiv : the preprint server for biology · 2025Article
- How the Structure of Signaling Regulation Evolves: Insights From an Evolutionary Model.Molecular biology and evolution · 2025Article
- A dual insect symbiont and plant pathogen improves insect host fitness under arginine limitation.mBio · 2025Article
- MiRNA Omics Reveal the Mechanisms of the Dual Effects of Selenium Supplementation on the Development of the Silkworm (International journal of molecular sciences · 2025Article
- Immune-Related Genes in the Honey Bee MiteInsects · 2025Article
119 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
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Abstract
The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-κB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.
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