ArticleJournal of theoretical biology2013
Modelling airway smooth muscle passive length adaptation via thick filament length distributions.
Article in Journal of theoretical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- A Distribution-Moment Approximation for Coupled Dynamics of the Airway Wall and Airway Smooth Muscle.Biophysical journal · 2018Article
- Airway Bistability Is Modulated by Smooth Muscle Dynamics and Length-Tension Characteristics.Biophysical journal · 2016Article
- Modeling the impairment of airway smooth muscle force by stretch.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- A biomechanical model for fluidization of cells under dynamic strain.Biophysical journal · 2015Article
- Phenotype, endotype and patient-specific computational modelling for optimal treatment design in asthma.Drug discovery today. Disease models · 2015Article
- Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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1 author at 1 institution in 1 country.
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Abstract
We present a new model of airway smooth muscle (ASM), which surrounds and constricts every airway in the lung and thus plays a central role in the airway constriction associated with asthma. This new model of ASM is based on an extension of sliding filament/crossbridge theory, which explicitly incorporates the length distribution of thick sliding filaments to account for a phenomenon known as dynamic passive length adaptation; the model exhibits good agreement with experimental data for ASM force-length behaviour across multiple scales. Principally these are (nonlinear) force-length loops at short timescales (seconds), parabolic force-length curves at medium timescales (minutes) and length adaptation at longer timescales. This represents a significant improvement on the widely-used crossbridge models which work so well in or near the isometric regime, and may have significant implications for studies which rely on crossbridge or other dynamic airway smooth muscle models, and thus both airway and lung dynamics.
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