ArticleThe American journal of drug and alcohol abuse2013
Longitudinal modeling of transmissible risk in boys who subsequently develop cannabis use disorder.
Article in The American journal of drug and alcohol abuse, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Physical inactivity during adolescence heightens risk for cannabis use disorder in adulthood.Experimental and clinical psychopharmacology · 2023Article
- Risky decision-making as an antecedent or consequence of adolescent cannabis use: findings from a 2-year longitudinal study.Addiction (Abingdon, England) · 2022Article
- Correlates of Cannabis Use Disorders among urban women of color: childhood abuse, relationship with spouse/partner, and media exposure.Journal of substance use · 2021Article
- Forecasting Opioid Use Disorder at 25 Years of Age in 16-Year-Old Adolescents.The Journal of pediatrics · 2020Article
- The association between alcohol use trajectories from adolescence to adulthood and cannabis use disorder in adulthood: a 22-year longitudinal study.The American journal of drug and alcohol abuse · 2017Article
- Longitudinal Studies on the Etiology of Cannabis Use Disorder: A Review.Current addiction reports · 2017Article
- The role of decision-making in cannabis-related problems among young adults.Drug and alcohol dependence · 2015Article
- Does the Transmissible Liability Index (TLI) assessed in late childhood predict suicidal symptoms at young adulthood?The American journal of drug and alcohol abuse · 2015Article
- Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder.Addictive behaviors · 2015Article
- A new approach to researching the etiology of cannabis use disorder: integrating transmissible and nontransmissible risk within a developmental framework.Substance abuse · 2014Article
- Application of person-centered medicine in addiction.International journal of person centered medicine · 2012Article
- WHY NOT POT?: A Review of the Brain-based Risks of Cannabis.Innovations in clinical neuroscienceReview
- Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRisk for substance use disorder is frequently transmitted across generations due to significant heritability.
objectiveThis longitudinal study tests the hypothesis that initial exposure to cannabis in youths having high transmissible risk is a signal event promoting development of cannabis use disorder (CUD).
methodsAt age 22, 412 men were classified into three groups: (1) lifetime CUD, (2) cannabis use without CUD, and (3) no lifetime cannabis use. Transmissible risk, quantified on a continuous scale using the previously validated transmissible liability index (TLI), along with cannabis use and CUD were documented at 10-12, 12-14, 16, 19, and 22 years of age.
resultsThe CUD group scored higher on the TLI before they began cannabis use compared to the other two groups. In addition, a progressive increase in TLI severity was evinced by the CUD group beginning at the time of initiation of cannabis use whereas cannabis users who did not subsequently develop CUD exhibited a decline in transmissible risk following first exposure.
conclusionInitial use of cannabis potentiates development of CUD in youths who are at high transmissible risk but is inconsequential in youths having low risk. The practical ramifications of these results for prevention are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.