ArticleVirology journal2013
Genetic diversity of Newcastle disease virus in Pakistan: a countrywide perspective.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Clinical and molecular identification of Newcastle disease virus in naturally infected chicks in Thi-Qar province of Iraq.Open veterinary journal · 2024Article
- Genomic Diversity and Evolutionary Insights of Avian Paramyxovirus-1 in Avian Populations in Pakistan.Viruses · 2024Article
- A Novel Recombinant Newcastle Disease Vaccine Improves Post-Vaccines · 2021Article
- Molecular and virological characterization of the first poultry outbreaks of Genotype VII.2 velogenic avian orthoavulavirus type 1 (NDV) in North-West Europe, BeNeLux, 2018.Transboundary and emerging diseases · 2021Article
- Genomic and biological characteristics of Avian Orthoavulavirus-1 strains isolated from multiple wild birds and backyard chickens in Pakistan.Tropical animal health and production · 2021Article
- Occurrence and Role of Selected RNA-Viruses as Potential Causative Agents of Watery Droppings in Pigeons.Pathogens (Basel, Switzerland) · 2020Review
- Efficacy of Thermostable Newcastle Disease Virus Strain I-2 in Broiler Chickens Challenged with Highly Virulent Newcastle Virus.Archives of Razi Institute · 2020Article
- Molecular epidemiology of respiratory viruses in commercial chicken flocks in Pakistan from 2014 through to 2016.BMC veterinary research · 2019Article
- Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Article
- A comparative genomic and evolutionary analysis of circulating strains of Avian avulavirus 1 in Pakistan.Molecular genetics and genomics : MGG · 2019Article
- Isolation, identification and molecular characterization of Newcastle disease viruses in vaccinated chickens from commercial farms in the Sultanate of Oman.International journal of veterinary science and medicine · 2018Article
- Molecular characterization of hemagglutinin-neuraminidase fragment gene of Newcastle disease virus isolated from periodically-vaccinated farms.Veterinary world · 2018Review
- Role of water chemistry and stabilizers on the Vero-cells-based infectivity of Newcastle disease virus live vaccine.The Journal of applied poultry research · 2018Article
- Adaptation of Newcastle Disease Virus (NDV) in Feral Birds and their Potential Role in Interspecies Transmission.The open virology journal · 2018Review
- Molecular Characterization of Newcastle Disease Virus from Backyard Poultry Farms and Live Bird Markets in Kenya.International journal of microbiology · 2018Article
- Pathotypic characterization of Newcastle disease virus isolated from vaccinated chicken in West Java, Indonesia.Veterinary world · 2017Article
- Genetic characterization and phylogeny of pigeon paramyxovirus isolate (PPMV-1) from Pakistan.SpringerPlus · 2016Article
- Effects of Chicken Interferon Gamma on Newcastle Disease Virus Vaccine Immunogenicity.PloS one · 2016Article
- Genetic characterization and pathogenicity assessment of Newcastle disease virus isolated from wild peacock.Virus genes · 2014Article
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNewcastle disease (ND) is one of the most deadly diseases of poultry around the globe. The disease is endemic in Pakistan and recurrent outbreaks are being reported regularly in wild captive, rural and commercial poultry flocks. Though, efforts have been made to characterize the causative agent in some of parts of the country, the genetic nature of strains circulating throughout Pakistan is currently lacking. MATERIAL AND
methodsTo ascertain the genetics of NDV, 452 blood samples were collected from 113 flocks, originating from all the provinces of Pakistan, showing high mortality (30-80%). The samples represented domesticated poultry (broiler, layer and rural) as well as wild captive birds (pigeons, turkeys, pheasants and peacock). Samples were screened with real-time PCR for both matrix and fusion genes (1792 bp), positive samples were subjected to amplification of full fusion gene and subsequent sequencing and phylogenetic analysis.
resultsThe deduced amino acid sequence of the fusion protein cleavage site indicated the presence of motif (112RK/RQRR↓F117) typical for velogenic strains of NDV. Phylogenetic analysis of hypervariable region of the fusion gene indicated that all the isolates belong to lineage 5 of NDV except isolates collected from Khyber Pakhtunkhwa (KPK) province. A higher resolution of the phylogenetic analysis of lineage 5 showed the distribution of Pakistani NDV strains to 5b. However, the isolates from KPK belonged to lineage 4c; the first report of such lineage from this province.
conclusionsTaken together, data indicated the prevalence of multiple lineages of NDV in different poultry population including wild captive birds. Such understanding is crucial to underpin the nature of circulating strains of NDV, their potential for interspecies transmission and disease diagnosis and control strategies.
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