ArticleBMC gastroenterology2013
The association between celiac disease and eosinophilic esophagitis in children and adults.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Natural history of eosinophilic esophagitis: a systematic review of epidemiology and disease course.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2018Pooled it
- Case Series: Is Celiac Disease Underdiagnosed in Korean Children?The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses.The journal of allergy and clinical immunology. Global · 2024Article
- Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis.Immunology and allergy clinics of North America · 2024Review
- Otorhinolaryngological Manifestations and Esophageal Disorders in Celiac Disease: A Narrative Review.Journal of clinical medicine · 2023Review
- Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022Article
- Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study.Nutrients · 2021Observational
- Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice-Which to Use Regarding Disease Outcomes?Antioxidants (Basel, Switzerland) · 2021Review
- Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.International journal of molecular sciences · 2020Review
- Diagnostic accuracy and applicability of intestinal auto-antibodies in the wide clinical spectrum of coeliac disease.EBioMedicine · 2020Article
- Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.Genes and immunity · 2019Article
- Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects.Esophagus : official journal of the Japan Esophageal Society · 2019Observational
- Pathophysiology of Eosinophilic Esophagitis.Clinical reviews in allergy & immunology · 2018Review
- Coeliac disease: to biopsy or not?Nature reviews. Gastroenterology & hepatology · 2018Review
- Eosinophilic oesophagitis and coeliac disease: is there an association?BMJ case reports · 2017Article
- Utility of Gastric and Duodenal Biopsies During Follow-up Endoscopy in Children With Eosinophilic Esophagitis.Journal of pediatric gastroenterology and nutrition · 2017Article
- Genetics of eosinophilic esophagitis.Mucosal immunology · 2017Review
- Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease.World journal of gastroenterology · 2017Article
- Increased Risk of Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients With Active Celiac Disease on Biopsy.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases.
methodsAll patients in a large Canadian city diagnosed with EoE or CD over a five-year period were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated.
resultsOver the five-year study EoE was diagnosed in 421 patients and CD was diagnosed in 763 patients. The incidence of EoE ranged from 2.1 to 10.7 cases per 100,000 population. The incidence of CD ranged from 10.4 to 15.7 cases per 100,000 population. Among the EoE cohort, 83 (20%) cases of EoE and 245 (32%) cases of CD were diagnosed in pediatric patients. The incidence of EoE in the pediatric subpopulation ranged from 3.7 to 6.9 cases per 100,000 population. The incidence of CD in the pediatric subpopulation ranged from 9.5 to 22.7 cases per 100,000 population. The concomitant diagnosis of both EoE and CD was made in three patients, all of whom were pediatric males. The SIR for EoE in the CD cohort was 48.4 (95% CI = 9.73, 141.41) with a SIR for CD within the paediatric EoE cohort of 75.05 (95% CI = 15.08, 219.28).
conclusionsThis study confirms the association between EoE and CD. However, this association may be limited to pediatrics where the risk of each condition is increased 50 to 75-fold in patients diagnosed with the alternative condition. The concomitant diagnosis of these conditions should be considered in pediatric patients with upper gastrointestinal symptoms.
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