ArticleClinical transplants2012
Immune responses to self-antigens (autoimmunity) in allograft rejection.
Article in Clinical transplants, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- New drugs for acute kidney injury.Journal of intensive medicine · 2025Review
- Ischemia Reperfusion Injury Induced Systemic Inflammatory Response Following Interspecies Liver Transplantation.Hepatic medicine : evidence and research · 2025Article
- Extracellular Vesicles Mediate Immune Responses to Tissue-Associated Self-Antigens: Role in Solid Organ Transplantations.Frontiers in immunology · 2022Review
- The role of exosomes in allograft immunity.Cellular immunology · 2018Review
- Cross-platform comparison of independent datasets identifies an immune signature associated with improved survival in metastatic melanoma.Oncotarget · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many lung, heart, and kidney transplant recipients with clinically as well as pathologically diagnosed chronic rejection don't have detectable antibodies directed to the mismatched donor HLA in their sera. This has led to the hypothesis that antibody responses to other tissue-restricted antigens may contribute to the development of chronic rejection. Development of immune responses to self-antigens has been described following all solid organ transplantations. Studies have further presented evidence for a significant cross talk between the alloimmune and autoimmune responses. Experimental results demonstrate that blocking of the immune responses to self-antigens may prevent chronic rejection. In this review, we present recent evidence for an important role of immune responses to self-antigens in the development of chronic rejection following transplantation. Further, we discuss the implications of these findings in developing new therapeutic strategies towards preventing or treating chronic rejection following transplantation.
Indexed as
Identifiers
23721031PMC5595349What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.