ArticleJournal of virology2013
Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Open questions in enterovirus uncoating.Journal of virology · 2026Review
- Phospho-activated non-muscle myosin IIA heavy chain supports different mechanisms of virus uptake.Journal of virology · 2025Article
- Cardiovascular-related death in infancy and childhood: a clinicopathological study of two referral institutions in England.Forensic science, medicine, and pathology · 2024Article
- Infections at the maternal-fetal interface: an overview of pathogenesis and defence.Nature reviews. Microbiology · 2022Review
- FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specializationFrontiers in immunology · 2022Article
- Slow Infection due to Lowering the Amount of Intact versus Empty Particles Is a Characteristic Feature of Coxsackievirus B5 Dictated by the Structural Proteins.Journal of virology · 2019Article
- The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection.Virus genes · 2019Article
- Type III interferon signaling restricts enterovirus 71 infection of goblet cells.Science advances · 2019Article
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- Cellular and molecular mechanisms of viral infection in the human placenta.Pathogens and disease · 2017Review
- Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line.Journal of pharmaceutical research international · 2017Article
- A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.Science advances · 2016Article
- Infectious Entry Pathway of Enterovirus B Species.Viruses · 2015Review
- ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.PLoS pathogens · 2015Article
- RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells.Cell host & microbe · 2015Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Maternal-fetal transmission of group B coxsackieviruses (CVB) during pregnancy has been associated with a number of diverse pathological outcomes, including hydrops fetalis, fetal myocarditis, meningoencephalitis, neurodevelopmental delays, congenital skin lesions, miscarriage, and/or stillbirth. Throughout pregnancy, the placenta forms a critical antimicrobial protective barrier at the maternal-fetal interface. Despite the severity of diseases accompanying fetal CVB infections, little is known regarding the strategies used by CVB to gain entry into placental trophoblasts. Here we used both a trophoblast cell line and primary human trophoblasts to demonstrate the mechanism by which CVB gains entry into polarized placental trophoblasts. Our studies revealed that the kinetics of CVB entry into placental trophoblasts are similar to those previously described for polarized intestinal epithelial cells. Likewise, CVB entry into placental trophoblasts requires decay-accelerating factor (DAF) binding and involves relocalization of the virus from the apical surface to intercellular tight junctions. In contrast, we have identified a divergent mechanism for CVB entry into polarized trophoblasts that is clathrin, caveolin-1, and dynamin II independent but requires intact lipid rafts. In addition, we found that members of the Src family of tyrosine kinases were required for CVB entry. Our studies highlight the complexity of viral entry into human placental trophoblasts and may serve as a model for mechanisms used by diverse pathogens to penetrate the placental barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.