ArticleJournal of biomedical research2013
Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese.
Article in Journal of biomedical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers.medRxiv : the preprint server for health sciences · 2026Article
- A genomic tale of inbreeding in western Mediterranean human populations.Human genetics · 2025Article
- Grid search approach to discriminate between old and recent inbreeding using phenotypic, pedigree and genomic information.BMC genomics · 2021Article
- Systematic analyses of genetic variants in chromatin interaction regions identified four novel lung cancer susceptibility loci.Journal of Cancer · 2020Article
- Regions of homozygosity as risk factors for multiple myeloma.Annals of human genetics · 2019Article
- Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females.Journal of Cancer · 2018Article
- Runs of homozygosity and inbreeding in thyroid cancer.BMC cancer · 2016Article
- Evidence of Inbreeding in Hodgkin Lymphoma.PloS one · 2016Article
- Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Progress of cancer genomics.Thoracic cancer · 2015Article
- Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages.American journal of human genetics · 2015Article
- Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study: principal components analysis vs. partial least squares.Journal of biomedical research · 2015Article
- Genetic risk of lung cancer associated with a single nucleotide polymorphism from EXO1: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- Human genome epidemiology, progress and future.Journal of biomedical research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Runs of homozygosity (ROHs) are a class of important but poorly studied genomic variations and may be involved in individual susceptibility to diseases. To better understand ROH and its relationship with lung cancer, we performed a genome-wide ROH analysis of a subset of a previous genome-wide case-control study (1,473 cases and 1,962 controls) in a Han Chinese population. ROHs were classified into two classes, based on lengths, intermediate and long ROHs, to evaluate their association with lung cancer risk using existing genome-wide single nucleotide polymorphism (SNP) data. We found that the overall level of intermediate ROHs was significantly associated with a decreased risk of lung cancer (odds ratio = 0.63; 95% confidence interval: 0.51-0.77; P = 4.78×10(-6) ), while the long ROHs seemed to be a risk factor of lung cancer. We also identified one ROH region at 14q23.1 that was consistently associated with lung cancer risk in the study. These results indicated that ROHs may be a new class of variation which may be associated with lung cancer risk, and genetic variants at 14q23.1 may be involved in the development of lung cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.