ArticleFrontiers in physiology2013
Links between copper and cholesterol in Alzheimer's disease.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- The role of intracellular and extracellular copper compartmentalization in Alzheimer's disease pathology and its implications for diagnosis and therapy.Frontiers in neuroscience · 2025Review
- Impact of aging on copper isotopic composition in the murine brain.Metallomics : integrated biometal science · 2024Article
- Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds.Current neuropharmacology · 2024Review
- Dietary Intake Levels of Iron, Copper, Zinc, and Manganese in Relation to Cognitive Function: A Cross-Sectional Study.Nutrients · 2023Article
- Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases.Computational and structural biotechnology journal · 2023Review
- Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study.NPJ aging and mechanisms of disease · 2021Article
- Review
- Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo.Molecular neurobiology · 2019Article
- Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
- Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease.Drug design, development and therapy · 2018Review
- Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.The Journal of biological chemistry · 2017Article
- Oxidative damage of copper chloride overload to the cultured rat astrocytes.American journal of translational research · 2016Article
- The many "faces" of copper in medicine and treatment.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2014Review
- From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.Advances in nutrition (Bethesda, Md.) · 2014Review
- Interactions of metals and Apolipoprotein E in Alzheimer's disease.Frontiers in aging neuroscience · 2014Review
- Reduced right frontal fractional anisotropy correlated with early elevated plasma LDL levels in obese young adults.PloS one · 2014Article
- Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Frontiers in aging neuroscience · 2014Review
- Neuroinflammation and copper in Alzheimer's disease.International journal of Alzheimer's disease · 2013Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered copper homeostasis and hypercholesterolemia have been identified independently as risk factors for Alzheimer's disease (AD). Abnormal copper and cholesterol metabolism are implicated in the genesis of amyloid plaques and neurofibrillary tangles (NFT), which are two key pathological signatures of AD. Amyloidogenic processing of a sub-population of amyloid precursor protein (APP) that produces Aβ occurs in cholesterol-rich lipid rafts in copper deficient AD brains. Co-localization of Aβ and a paradoxical high concentration of copper in lipid rafts fosters the formation of neurotoxic Aβ:copper complexes. These complexes can catalytically oxidize cholesterol to generate H2O2, oxysterols and other lipid peroxidation products that accumulate in brains of AD cases and transgenic mouse models. Tau, the core protein component of NFTs, is sensitive to interactions with copper and cholesterol, which trigger a cascade of hyperphosphorylation and aggregation preceding the generation of NFTs. Here we present an overview of copper and cholesterol metabolism in the brain, and how their integrated failure contributes to development of AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.