ArticleJournal of the Royal Society, Interface2013
Genomic mutation rates that neutralize adaptive evolution and natural selection.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Lethal mutagenesis and the transient within-host dynamics of viral adaptation.Virus evolution · 2025Article
- Continuous evolution of user-defined genes at 1 million times the genomic mutation rate.Science (New York, N.Y.) · 2024Article
- Sex-specific viability effects of mutations in Drosophila melanogaster.Evolution; international journal of organic evolution · 2024Article
- Review
- Thermodynamics of evolution and the origin of life.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The adaptive potential of circular DNA accumulation in ageing cells.Current genetics · 2020Review
- Article
- Mutation and Selection in Bacteria: Modelling and Calibration.Bulletin of mathematical biology · 2019Article
- High mutation rates limit evolutionary adaptation in Escherichia coli.PLoS genetics · 2018Article
- Evolution with a seed bank: The population genetic consequences of microbial dormancy.Evolutionary applications · 2018Review
- Arresting Evolution.Trends in genetics : TIG · 2017Review
- Article
- Dynamics and Fate of Beneficial Mutations Under Lineage Contamination by Linked Deleterious Mutations.Genetics · 2017Article
- Two sides of the same coin: A population genetics perspective on lethal mutagenesis and mutational meltdown.Virus evolution · 2017Article
- Genetic drift, selection and the evolution of the mutation rate.Nature reviews. Genetics · 2016Review
- RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence.Cell host & microbe · 2016Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
When mutation rates are low, natural selection remains effective, and increasing the mutation rate can give rise to an increase in adaptation rate. When mutation rates are high to begin with, however, increasing the mutation rate may have a detrimental effect because of the overwhelming presence of deleterious mutations. Indeed, if mutation rates are high enough: (i) adaptive evolution may be neutralized, resulting in a zero (or negative) adaptation rate despite the continued availability of adaptive and/or compensatory mutations, or (ii) natural selection may be neutralized, because the fitness of lineages bearing adaptive and/or compensatory mutations--whether established or newly arising--is eroded by excessive mutation, causing such lineages to decline in frequency. We apply these two criteria to a standard model of asexual adaptive evolution and derive mathematical expressions--some new, some old in new guise--delineating the mutation rates under which either adaptive evolution or natural selection is neutralized. The expressions are simple and require no a priori knowledge of organism- and/or environment-specific parameters. Our discussion connects these results to each other and to previous theory, showing convergence or equivalence of the different results in most cases.
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