ArticleThe American journal of pathology1990
Helium-neon laser treatment transforms fibroblasts into myofibroblasts.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 150 citations in OpenAlex.
- New 675 nm Laser Device: The Innovative and Effective Non-Ablative Resurfacing Technique.Medicina (Kaunas, Lithuania) · 2023Article
- Development of Wide-Angle Short-Wave Pass Thin Film Based on the Ultra-Thin Silicate Glass.Materials (Basel, Switzerland) · 2022Article
- Article
- Gingival Melanin Depigmentation Using a Diode 808-nm Laser: A Case Series.Journal of lasers in medical sciences · 2022Article
- Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.Scientific reports · 2021Article
- Photobiomodulation and Oral Mucositis: A Systematic Review.Dentistry journal · 2020Review
- Bisphosphonate-related osteonecrosis of the jaw: a review of the potential efficacy of low-level laser therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Review
- Evaluation of Patient Perceptions After Vestibuloplasty Procedure: A Comparison of Diode Laser and Scalpel Techniques.Journal of clinical and diagnostic research : JCDR · 2016Article
- Medication-Related Osteonecrosis of Jaws: A Low-Level Laser Therapy and Antimicrobial Photodynamic Therapy Case Approach.Case reports in dentistry · 2016Article
- Efficacy of LLLT in swelling and pain control after the extraction of lower impacted third molars.Laser therapy · 2015Article
- In vitro Therapeutic Effects of Low Level Laser at mRNA Level on the Release of Skin Growth Factors from Fibroblasts in Diabetic Mice.Avicenna journal of medical biotechnology · 2014Article
- The effects of low-level laser irradiation on cellular viability and proliferation of human skin fibroblasts cultured in high glucose mediums.Lasers in medical science · 2014Article
- Low-level laser therapy: an experimental design for wound management: a case-controlled study in rabbit model.Journal of cutaneous and aesthetic surgery · 2014Article
- High-power helium-neon laser irradiation inhibits the growth of traumatic scars in vitro and in vivo.Lasers in medical science · 2013Article
- Influence of three laser wavelengths on human fibroblasts cell culture.Lasers in medical science · 2013Article
- Laser in dentistry: An innovative tool in modern dental practice.National journal of maxillofacial surgery · 2012Article
- Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells.Lasers in medical science · 2012Review
- The influence of He-Ne laser on scar formation after trabeculectomy in rabbits.International journal of ophthalmology · 2010Article
- Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in Wistar rats.Indian journal of dermatology · 2009Article
- Laser light influences cellular viability and proliferation in diabetic-wounded fibroblast cells in a dose- and wavelength-dependent manner.Lasers in medical science · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of myofibroblastic cells from normal human gingival fibroblasts in vitro has been established by transmission electron microscopy and quantitated by immunohistochemistry, using antigelsolin monoclonal antibodies. Untreated control cultures were compared to cultures exposed to Helium-Neon (He-Ne) laser irradiation. A direct and massive transformation of the cultured fibroblasts into myofibroblasts was observed as early as 24 hours after laser treatment, whereas control cultures were comprised of only resting fibroblasts and active fibroblasts. This in vitro induction of myofibroblasts may be analogous to that which occurs in vivo. Therefore we undertook a similar study using biopsies from gingival tissues after wisdom tooth extraction. Myofibroblasts were present in the connective tissue of laser-treated gums 48 hours after irradiation, but not in untreated contralateral control tissues. These data provide evidence that the primary biologic effect of the Helium-Neon laser on connective tissue is the rapid generation of myofibroblasts from fibroblasts. The induction of a phenotype with contractile properties may have clinical significance in the acceleration of the wound-healing process.
Indexed as
Identifiers
2372040PMC1877706W1507522724What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.