ArticleThe American journal of pathology1990
Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- Organizing Pneumonia in a Patient with Pulmonary Transthyretin Amyloidosis.Internal medicine (Tokyo, Japan) · 2026Article
- Connective tissue disease-associated lung disease in children.Pediatric radiology · 2024Review
- The many faces of cryptogenic organizing pneumonia (COP).Journal of clinical imaging science · 2022Article
- The Therapeutic Potential of Anticoagulation in Organ Fibrosis.Frontiers in medicine · 2022Review
- Total serum IL-6 and TNF-C levels in children with bronchopneumonia following treatment with methylprednisolone in combination with azithromycin.American journal of translational research · 2021Article
- Clinical features of acute fibrinous and organizing pneumonia: An early histologic pattern of various acute inflammatory lung diseases.PloS one · 2021Article
- The fibrotic tumor stroma.The Journal of clinical investigation · 2018Review
- The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography.Polish journal of radiology · 2014Article
- Organizing pneumonia: a kaleidoscope of concepts and morphologies.European radiology · 2011Review
- Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?British journal of pharmacology · 2008Review
- Review
- Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis.The American journal of pathology · 2005Article
- Organising pneumonia.Thorax · 2000Review
- Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma.The American journal of pathology · 1997Article
- Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.The Journal of clinical investigation · 1996Article
- Fibrosing vasculitis in Wegener's granulomatosis: ultrastructural and immunohistochemical analysis of the vascular lesions.Virchows Archiv : an international journal of pathology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic bronchiolitis obliterans-organizing pneumonia (BOOP) is characterized by air space fibrosis of unknown origin. Clinical resolution under steroid treatment suggests the removal of the fibrotic lesion. Open lung biopsies of four patients with idiopathic BOOP were studied by immunochemistry and electron microscopy. Three distinct cell-matrix patterns of intra-alveolar bud were found to represent the sequential evolution of the fibrotic process: fibrinoid inflammatory cell clusters in which immunoglobulins and procoagulant factors (fibrinogen, factors VII and X) were identified; fibroinflammatory buds in which desmin-containing fibroblasts were observed migrating, proliferating, and secreting matrix proteins; fibrotic buds in which myofibroblasts organized a loose connective matrix predominantly composed of fibronectin and type III collagen. Extending forms of fibrotic buds may join contiguous alveoli. Fibrotic bud remodeling ability is correlated to the nature and organization of the matrix components but the factors permitting intra-alveolar matrix degradation must be characterized.
Indexed as
Identifiers
2372039PMC1877710W2275592946What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.