ReviewComprehensive Physiology2013
Comparative digestive physiology.
Review in Comprehensive Physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 2 syntheses or guidelines pooled it, 317 citations in OpenAlex.
- Intraspecific Trait Variation in the Mammalian Gastrointestinal Tract: A Digestive Dive and Systematic Literature Review.Integrative and comparative biology · 2026Pooled it
- A Meta-Analysis of Mercury Biomagnification in Freshwater Predatory Invertebrates: Community Diversity and Dietary Exposure Drive Variability.Environmental science & technology · 2024Pooled it
- Impact of oral administration of single strainFrontiers in immunology · 2022Trial
- Feeding biomechanics in vertebrates and beyond.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Metabolic flexibility and seasonal physiological responses of the resident silverside Odontesthes argentinensis in a southwestern Atlantic coastal lagoon.Journal of fish biology · 2026Article
- Convergent digestive adaptation to resource limitation in an insular lizard across a microgeographic archipelago.The Journal of animal ecology · 2026Article
- Metabolomic insights into the response strategies of bats to high-glucose stimulation.Zoological research · 2026Article
- Species-Specific Bacterial Associations Emerge From Stochastically Assembled Microbiomes in Northeastern American Fireflies.Molecular ecology · 2026Article
- Early Post-Release Movement Convergence in Reintroduced Giant Pandas.Ecology and evolution · 2026Article
- Molluscivorous red knots rapidly adjust to a plant diet.Biology open · 2026Article
- Behavioral Selection of Coprophagy in an Arid-Adapted Herbivore: Does a Compatibility-Risk Gradient Shape Selective Coprophagy?Ecology and evolution · 2026Article
- Diet Outweighs Vertical Transmission in Shaping Dung Beetle Larval Gut Microbiomes.Molecular ecology · 2026Article
- Reciprocal Hybridization Between Herbivorous and Carnivorous Sub-Cold-Water Fish Reveals Divergent Intestinal Characteristics and Microbiome Assembly.Animals : an open access journal from MDPI · 2026Article
- Plant- and Microalgae-Based Biotechnological Strategies for Affordable and Non-Invasive Delivery of Antidiabetic Peptides.Pharmaceutics · 2026Review
- Mussels enhance digestive enzyme activity in preparation for stressful fluctuating environments.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- Article
- What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Digestive Enzyme Activity and Temperature: Evolutionary Constraint or Physiological Flexibility?Animals : an open access journal from MDPI · 2025Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In vertebrates and invertebrates, morphological and functional features of gastrointestinal (GI) tracts generally reflect food chemistry, such as content of carbohydrates, proteins, fats, and material(s) refractory to rapid digestion (e.g., cellulose). The expression of digestive enzymes and nutrient transporters approximately matches the dietary load of their respective substrates, with relatively modest excess capacity. Mechanisms explaining differences in hydrolase activity between populations and species include gene copy number variations and single-nucleotide polymorphisms. Transcriptional and posttranscriptional adjustments mediate phenotypic changes in the expression of hydrolases and transporters in response to dietary signals. Many species respond to higher food intake by flexibly increasing digestive compartment size. Fermentative processes by symbiotic microorganisms are important for cellulose degradation but are relatively slow, so animals that rely on those processes typically possess special enlarged compartment(s) to maintain a microbiota and other GI structures that slow digesta flow. The taxon richness of the gut microbiota, usually identified by 16S rRNA gene sequencing, is typically an order of magnitude greater in vertebrates than invertebrates, and the interspecific variation in microbial composition is strongly influenced by diet. Many of the nutrient transporters are orthologous across different animal phyla, though functional details may vary (e.g., glucose and amino acid transport with K+ rather than Na+ as a counter ion). Paracellular absorption is important in many birds. Natural toxins are ubiquitous in foods and may influence key features such as digesta transit, enzymatic breakdown, microbial fermentation, and absorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.