ArticleProceedings of the National Academy of Sciences of the United States of America2013
SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 127 citations in OpenAlex.
- Evolution and functional characterization of the MdSKP8 gene as a conserved hub integrating hormone and antioxidant pathways for salt tolerance in apple.Plant cell reports · 2026Article
- Stress drives plasticity in leaf ageing transcriptional dynamics in Arabidopsis thaliana.Nature plants · 2026Article
- Elucidating the differential antiviral action of a plant growth promoting rhizobacterium against three genetically distant virus species.Frontiers in plant science · 2026Article
- Cytokinin signaling mediated by KMD2 promotes Arabidopsis hypocotyl grafting success.microPublication biology · 2026Article
- Unlocking the Genetic Blueprint of Erucic Acid Content in Mustard (Brassica napus): A Meta-QTL Exploration.TheScientificWorldJournal · 2026Article
- Article
- Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation.bioRxiv : the preprint server for biology · 2025Article
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Melatonin at Crossroads with Phytohormones: Interactions Under High Light Stress.International journal of molecular sciences · 2025Article
- Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection.Plant communications · 2025Article
- Comparative transcriptome analysis of oat varieties with different flowering performances under a short-day photoperiod.BMC plant biology · 2025Article
- The TATA-box binding protein-associated factor TAF12b facilitates the degradation of type B response regulators to negatively regulate cytokinin signaling.Plant communications · 2024Article
- Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development.Molecular plant pathology · 2024Article
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- Factors governing cellular reprogramming competence in Arabidopsis adventitious root formation.Developmental cell · 2024Article
- Interactions between Brassinosteroids and Strigolactones in Alleviating Salt Stress in Maize.International journal of molecular sciences · 2024Article
- HIGH PLOIDY2-mediated SUMOylation of transcription factor ARR1 controls two-component signaling in Arabidopsis.The Plant cell · 2024Article
- Identification of tomato F-box proteins functioning in phenylpropanoid metabolism.Plant molecular biology · 2024Article
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- The Role of Cytokinins during the Development of Strawberry Flowers and Receptacles.Plants (Basel, Switzerland) · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinins are plant hormones that play critical roles in growth and development. In Arabidopsis, the transcriptional response to cytokinin is regulated by action of type-B Arabidopsis response regulators (ARRs). Although central elements in the cytokinin signal transduction pathway have been identified, mechanisms controlling output remain to be elucidated. Here we demonstrate that a family of F-box proteins, called the kiss me deadly (KMD) family, targets type-B ARR proteins for degradation. KMD proteins form an S-phase kinase-associated PROTEIN1 (SKP1)/Cullin/F-box protein (SCF) E3 ubiquitin ligase complex and directly interact with type-B ARR proteins. Loss-of-function KMD mutants stabilize type-B ARRs and exhibit an enhanced cytokinin response. In contrast, plants with elevated KMD expression destabilize type-B ARR proteins leading to cytokinin insensitivity. Our results support a model in which an SCF(KMD) complex negatively regulates cytokinin responses by controlling levels of a key family of transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.