ArticleJournal of biomechanical engineering2013
Multiscale mechanical simulations of cell compacted collagen gels.
Article in Journal of biomechanical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Measuring alignment of structural proteins in engineered tissue constructs using polarized Raman spectroscopy.PloS one · 2025Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Multiscale mechanical characterization and computational modeling of fibrin gels.Acta biomaterialia · 2023Article
- Polymeric reinforcements for cellularized collagen-based vascular wall models: influence of the scaffold architecture on the mechanical and biological properties.Frontiers in bioengineering and biotechnology · 2023Article
- Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale.Research (Washington, D.C.) · 2023Article
- Long-range mechanical signaling in biological systems.Soft matter · 2021Review
- Multi-cell ECM compaction is predictable via superposition of nonlinear cell dynamics linearized in augmented state space.PLoS computational biology · 2019Article
- Recent Advances in Engineering the Stem Cell Microniche in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Review
- Constitutive modeling of compressible type-I collagen hydrogels.Medical engineering & physics · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Toughening of fibrous scaffolds by mobile mineral deposits.Acta biomaterialia · 2017Article
- The fibrous cellular microenvironment, and how cells make sense of a tangled web.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The tendon-to-bone attachment: Unification through disarray.Nature materials · 2017Article
- Cell Contractility Facilitates Alignment of Cells and Tissues to Static Uniaxial Stretch.Biophysical journal · 2017Article
- Fiber Network Models Predict Enhanced Cell Mechanosensing on Fibrous Gels.Journal of biomechanical engineering · 2016Article
- Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.Annals of biomedical engineering · 2016Review
- Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold model.Journal of the mechanical behavior of biomedical materials · 2016Article
- Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction.Journal of biomechanical engineering · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Engineered tissues are commonly stretched or compressed (i.e., conditioned) during culture to stimulate extracellular matrix (ECM) production and to improve the mechanical properties of the growing construct. The relationships between mechanical stimulation and ECM remodeling, however, are complex, interdependent, and dynamic. Thus, theoretical models are required for understanding the underlying phenomena so that the conditioning process can be optimized to produce functional engineered tissues. Here, we continue our development of multiscale mechanical models by simulating the effect of cell tractions on developing isometric tension and redistributing forces in the surrounding fibers of a collagen gel embedded with explants. The model predicted patterns of fiber reorganization that were similar to those observed experimentally. Furthermore, the inclusion of cell compaction also changed the distribution of fiber strains in the gel compared to the acellular case, particularly in the regions around the cells where the highest strains were found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.