ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2013
Low iron storage and mild anemia in postural tachycardia syndrome in adolescents.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 37 citations in OpenAlex.
- Postural tachycardia during active standing: diagnostic criteria in adolescents.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- A Study of Dizziness or Vertigo Cases Associated with Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis) in a Vertigo Outpatient Clinic.Journal of clinical medicine · 2025Article
- Iron deficiency responses and integrated compensations in patients according to hereditary hemorrhagic telangiectasiaHaematologica · 2024Article
- Effect of lower body negative pressure on cardiac and cerebral function in postural orthostatic tachycardia syndrome: A pilot MRI assessment.Physiological reports · 2024Article
- Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature.Human antibodies · 2023Article
- Narrative Review of Postural Orthostatic Tachycardia Syndrome: Associated Conditions and Management Strategies.US cardiology · 2023Review
- Biomarkers and Hemodynamic Parameters in the Diagnosis and Treatment of Children with Postural Tachycardia Syndrome and Vasovagal Syncope.International journal of environmental research and public health · 2022Review
- Restless legs syndrome is increased in postural orthostatic tachycardia syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome.BMC cardiovascular disorders · 2020Article
- Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management.Frontiers in pediatrics · 2020Review
- Update of Individualized Treatment Strategies for Postural Orthostatic Tachycardia Syndrome in Children.Frontiers in neurology · 2020Review
- Pubertal Hormonal Changes and the Autonomic Nervous System: Potential Role in Pediatric Orthostatic Intolerance.Frontiers in neuroscience · 2019Review
- How to Care for Adolescent Patients With Orthostatic Intolerance in the Primary Care Office.Journal of primary care & community healthArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveWe reported low iron storage in neurally mediated syncope (NMS). While reduced red cell mass indicative of anemia has been reported in POTS, iron indices and hemoglobin (Hb) data were not reported. We investigated whether POTS, like NMS, is associated with low iron storage and anemia.
methodsThirty two children evaluated in 2007 and 2008 for probable POTS by a standing or tilt test or both at Texas Children's Hospital were included in a retrospective study. We measured serum ferritin (SF) and Hb values. We defined iron deficiency as SF < 12 μg/L, low iron storage as SF ≤ 25 μg/L, anemia as low Hb values for age and sex, and POTS as ≥2 symptoms of orthostatic intolerance >3 months and increased HR of >30 BPM or HR of >120 BPM within 10 min of standing or 70° tilt.
resultsTwenty four children had POTS, ages 12-18 years, 17 (71 %) were females. Value range (median) of SF 2-289 μg/L (25), Hb 11.5-14.6 (12.5) in females and 12-15.9 g/L (13.6) in males. Patients with POTS, when compared with normal US pediatric population had higher prevalence of low iron storage (50 vs. 14 %), iron deficiency (25 % of teenage girls vs. 9 %, and 16 % of teenage boys vs. 1 %), and anemia (18 % of teenage girls vs. 1.5 %, and 43 % of teenage boys vs. 0.1 %).
interpretationLow iron storage and mild anemia are associated with POTS suggesting that low iron storage is a potentially pathophysiologic factor in both POTS and NMS.
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