ArticleCancer discovery2013
Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
Article in Cancer discovery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
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- Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis.MedComm · 2024Article
- Take metabolic heterogeneity into consideration when applying dietary interventions to cancer therapy: A review.Heliyon · 2023Review
- Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development.Cold Spring Harbor perspectives in medicine · 2021Review
- ENTPD5: identification of splicing variants and their impact on cancer survival.Purinergic signalling · 2021Article
- A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.Cancer discovery · 2021Article
- DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.PLoS genetics · 2021Article
- [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Dietary modifications for enhanced cancer therapy.Nature · 2020Review
- A framework for examining how diet impacts tumour metabolism.Nature reviews. Cancer · 2019Review
- RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas.Acta neuropathologica · 2019Article
- Ablation of insulin receptor substrates 1 and 2 suppressesProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.Oncogene · 2018Article
- Critical role for arginase 2 in obesity-associated pancreatic cancer.Nature communications · 2017Article
- Article
- Cell intrinsic and extrinsic regulation of leukemia cell metabolism.International journal of hematology · 2016Review
- Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer.Oncogenesis · 2016Review
- AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow.Cell stem cell · 2015Article
- Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
PTEN loss is considered a biomarker for activated phosphoinositide 3-kinase (PI3K)/AKT, a pathway frequently mutated in cancer, and was recently shown to confer resistance to dietary restriction. Here, we show that Pten loss is not sufficient to drive AKT activation and resistance to dietary restriction in tumors with low growth factor receptor levels. We describe a murine Pten-null Kras-driven lung cancer model that harbors both dietary restriction-resistant, higher-grade, bronchiolar tumors with high AKT activity, and dietary restriction-sensitive, lower-grade, alveolar tumors with low AKT activity. We find that this phenotype is cell autonomous and that normal bronchiolar cells express higher levels of insulin-like growth factor-I receptor (IGF-IR) and of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), an endoplasmic reticulum enzyme known to modulate growth factor receptor levels. Suppression of ENTPD5 is sufficient to decrease IGF-IR levels and sensitize bronchiolar tumor cells to serum in vitro and to dietary restriction in vivo. Furthermore, we find that a significant percentage of human non-small cell lung carcinomas (NSCLC) have low AKT activity despite PTEN loss.
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Registered trials
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