ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Downstaging advanced hepatocellular carcinoma to the Milan criteria may provide a comparable outcome to conventional Milan criteria.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Review
- Survival outcomes after surgical resection of huge HCC (≥ 10 cm) with or without neoadjuvant hepatic arterial infusion chemotherapy.World journal of surgical oncology · 2025Article
- A Metrology Informatics Investigation of Conversion Therapy in Hepatocellular Carcinoma: 2014-2023.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Predicting the outcomes of hepatocellular carcinoma downstaging with the use of clinical and radiomics features.BMC cancer · 2023Article
- Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2023Review
- Neoadjuvant treatment strategies for hepatocellular carcinoma.World journal of gastrointestinal surgery · 2021Review
- Long-term outcomes of living donor liver transplantation after locoregional treatment for hepatocellular carcinoma: an experience from a single institute.Surgery today · 2021Article
- The Real Impact of Bridging or Downstaging on Survival Outcomes after Liver Transplantation for Hepatocellular Carcinoma.Liver cancer · 2020Article
- The Timing of Liver Transplantation Following Downstaging: Wait of Not to Wait?Journal of gastrointestinal cancer · 2020Review
- Microwave ablation after downstaging of hepatocellular carcinoma: outcome was similar to tumor within Milan criteria.European radiology · 2020Article
- Regional Chemotherapy for Biliary Tract Tumors and Hepatocellular Carcinoma.Surgical oncology clinics of North America · 2019Review
- Response to transarterial chemoembolization may serve as selection criteria for hepatocellular carcinoma liver transplantation.Oncotarget · 2017Article
- Liver transplantation for hepatobiliary malignancies: a new era of "Transplant Oncology" has begun.Surgery today · 2017Review
- Liver Transplantation After Transarterial Chemoembolization and Radiotherapy for Hepatocellular Carcinoma with Vascular Invasion.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Trans-arterial radio-embolization: a new chance for patients with hepatocellular cancer to access liver transplantation, a world review.Translational gastroenterology and hepatology · 2017Review
- Hepatocellular carcinoma: when is liver transplantation oncologically futile?Translational gastroenterology and hepatology · 2017Review
- Yttrium-90 Radioembolization for Hepatocellular Carcinoma Prior to Liver Transplantation.World journal of surgery · 2017Article
- Living Donor Liver Transplantation for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis after Concurrent Chemoradiation Therapy.Yonsei medical journal · 2016Article
- Diagnostic and Therapeutic Approaches to Hepatocellular Carcinoma: Understanding the Barcelona Clínic Liver Cancer Protocol.Clinical medicine insights. Gastroenterology · 2016Review
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3 authors.
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Abstract
BACKGROUND AND
aimsMany hepatocellular carcinoma (HCC) patients met the appropriate criteria and accepted liver transplantation after successful downstaging therapies; however, the outcome in these patients is unclear. We aim to compare the outcome of patients meeting the Milan criteria at the beginning and after successful downstaging therapies. PATIENTS AND
methodsBetween July 2001 and January 2013, 112 patients were diagnosed with early-stage HCC that met the Milan criteria. Of these patients, 58 patients did not meet the Milan criteria initially but did after successful downstaging therapies. We retrospectively collected and then compared the baseline characteristics, postoperative complications, survival rate, and tumor recurrence rate of these two groups. Kaplan-Meier analyses were used to estimate the long-term overall survival and tumor-free survival in these patients.
resultsNo significant differences were observed between the two groups with respect to baseline donor and recipient characteristics. The downstaging Milan group showed similar tumor characteristics compared to the conventional Milan group, except the downstaging group had better tumor histopathologic grading (P = 0.027). The 1-, 3-, and 5-year overall survival rates were comparable at 91.4, 82.8, and 70.7 %, respectively, in the downstaging Milan criteria and 92.0, 85.7, and 74.1 %, respectively, according to the initial Milan criteria (P = 0.540). The 1-, 3-, and 5-year tumor-free survival rates between the two groups were not statistically significant (P = 0.667).
conclusionSuccessful downstaging therapies can provide a comparable posttransplantation overall survival and tumor-free survival rates after liver transplantation.
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