ArticleScientific reports2013
Directed self-assembly of proteins into discrete radial patterns.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Supramolecular assembly of protein building blocks: from folding to function.Nano convergence · 2022Review
- Self-Assembly of Human Serum Albumin: A Simplex Phenomenon.Biomolecules · 2017Article
- Tug-of-war of microtubule filaments at the boundary of a kinesin- and dynein-patterned surface.Scientific reports · 2014Article
- Artificial photosynthesis of oxalate and oxalate-based polymer by a photovoltaic reactor.Scientific reports · 2014Article
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Authors and funding
3 authors.
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Abstract
Unlike physical patterning of materials at nanometer scale, manipulating soft matter such as biomolecules into patterns is still in its infancy. Self-assembled monolayer (SAM) with surface density gradient has the capability to drive biomolecules in specific directions to create hierarchical and discrete structures. Here, we report on a two-step process of self-assembly of the human serum albumin (HSA) protein into discrete ring structures based on density gradient of SAM. The methodology involves first creating a 2-dimensional (2D) polyethylene glycol (PEG) islands with responsive carboxyl functionalities. Incubation of proteins on such pre-patterned surfaces results in direct self-assembly of protein molecules around PEG islands. Immobilization and adsorption of protein on such structures over time evolve into the self-assembled patterns.
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