ArticleNature2013
The role of epistasis in protein evolution.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Evolutionary pathways in epistatic mechanical networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effect of Mutations on the Evolution of Extended Spectrum β-lactamases (ESBL).The protein journal · 2025Review
- Article
- Design of a Protein with Improved Thermal Stability by an Evolution-Based Generative Model.Angewandte Chemie (International ed. in English) · 2022Article
- Intragenic compensation through the lens of deep mutational scanning.Biophysical reviews · 2022Review
- Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes.Nature communications · 2022Article
- Article
- Senescence and entrenchment in evolution of amino acid sites.Nature communications · 2020Article
- Harnessing Conformational Plasticity to Generate Designer Enzymes.Journal of the American Chemical Society · 2020Review
- Article
- Evolution of chalcone isomerase from a noncatalytic ancestor.Nature chemical biology · 2018Article
- Pervasive contingency and entrenchment in a billion years of Hsp90 evolution.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli.Scientific reports · 2017Article
- Parallel Evolution of Metazoan Mitochondrial Proteins.Genome biology and evolution · 2017Article
- Detecting Adaptation in Protein-Coding Genes Using a Bayesian Site-Heterogeneous Mutation-Selection Codon Substitution Model.Molecular biology and evolution · 2017Article
- A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.Genetics · 2016Article
- The tangled bank of amino acids.Protein science : a publication of the Protein Society · 2016Article
- Article
- Epistasis in protein evolution.Protein science : a publication of the Protein Society · 2016Review
- Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
23719465What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.