Evidence map›Paper›PMID 23719259›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013

The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer.

Liselle C Bovell, Chandrakumar Shanmugam, Balananda-Dhurjati K Putcha, Venkat R Katkoori, Bin Zhang, Sejong Bae, Karan P Singh, William E Grizzle, Upender Manne

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 13 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 13 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Liselle C BovellDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Chandrakumar Shanmugam
Balananda-Dhurjati K Putcha
Venkat R Katkoori
Bin Zhang
Sejong Bae
Karan P Singh
William E Grizzle
Upender Manne
University of Alabama at Birmingham · US

Funding

TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Timiya S Nolan · 2005 to 2026
$26.6M
UAB Rexinoids for Breast Cancer PreventionP50CA089019 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOPEZ, RICHARD D · 2000 to 2011
$26.0M
Research Education CoreU54CA118623 · NCI · TUSKEGEE UNIVERSITY · PI STEPHEN O SODEKE · 2005 to 2026
$20.2M
Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
INFRASTRUCTURE IIG12MD007585 · NIMHD · TUSKEGEE UNIVERSITY · PI YATES, CLAYTON · 2012 to 2016
$4.6M
Prognostic Molecular Markers of Colorectal CancerR01CA098932 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MANNE, UPENDER · 2003 to 2009
$1.5M
NCI NIH HHS 2U54-CA118948NCI NIH HHS 5R25 CA47888NCI NIH HHS CA098932NCI NIH HHS P50 CA089019NCI NIH HHS R01 CA098932NCI NIH HHS R25 CA047888NCI NIH HHS U54 CA118623NCI NIH HHS U54 CA118948NIMHD NIH HHS G12 MD007585
6 · The paper itself

Abstract

purposeMicroRNAs (miRNA) have potential prognostic value for colorectal cancers; however, their value based on patient race/ethnicity and pathologic stage has not been determined. The goal was to ascertain the prognostic value of 5 miRNAs with increased expression in colorectal cancers of African American (black) and non-Hispanic Caucasian (white) patients. EXPERIMENTAL

designTaqMan quantitative real-time PCR was used to quantify expression of miR-20a, miR-21, miR-106a, miR-181b, and miR-203 in paired normal and tumor colorectal cancer archival tissues collected from 106 black and 239 white patients. The results were correlated with overall survival based on patient race/ethnicity and pathologic stage. Because decisions about adjuvant therapy are important for stage III colorectal cancers, and because miR-181b seemed to have prognostic value only for stage III black patients, we assessed its prognostic value in a separate cohort of 36 stage III colorectal cancers of blacks.

resultsAll 5 miRNAs had higher expression in colorectal cancers (>1.0-fold) than in corresponding normal tissues. High expression of miR-203 was associated with poor survival of whites with stage IV colorectal cancers (HR = 3.00; 95% CI, 1.29-7.53), but in blacks it was an indicator of poor survival of patients with stages I and II colorectal cancers (HR = 5.63; 95% CI, 1.03-30.64). Increased miR-21 expression correlated with poor prognosis for white stage IV patients (HR = 2.50; 95% CI, 1.07-5.83). In both test and validation cohorts, high miR-181b expression correlated with poor survival of only black patients with stage III colorectal cancers (HR = 1.94; 95% CI, 1.03-3.67).

conclusionThese preliminary findings suggest that the prognostic value of miRNAs in colorectal cancers varies with patient race/ethnicity and stage of disease.

Indexed as

AgedBiomarkers, TumorBlack or African AmericanColorectal NeoplasmsFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMicroRNAsMiddle AgedNeoplasm StagingPrognosisProportional Hazards ModelsWhite PeopleBiomarkers, TumorMicroRNAsMIRN106 microRNA, humanMIrn181 microRNA, humanMIRN203 microRNA, humanMIRN20a microRNA, humanMIRN21 microRNA, human

Identifiers

PMID23719259
PMCPMC3746330
OpenAlexW2169738147

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.