ReviewBiomatter
Synthesis of spherical calcium phosphate particles for dental and orthopedic applications.
Review in Biomatter. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 139 citations in OpenAlex.
- High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.Bioactive materials · 2026Article
- Effect of Fluoride Varnishes Containing Casein Phosphopeptide-amorphous Calcium Phosphate on Primary Enamel Microhardness: AnInternational journal of clinical pediatric dentistry · 2026Article
- Synthesis and Application of Sustainable Tricalcium Phosphate Based Biomaterials From Agro-Based Materials: A Review.Biomedical engineering and computational biology · 2024Review
- Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.Frontiers in bioengineering and biotechnology · 2024Article
- Process optimization for the rapid conversion of calcite into hydroxyapatite microspheres for chromatographic applications.Scientific reports · 2022Article
- Rational design and fabrication of monophasic bioceramic microspheres with enhanced mechanical and biological performances in reconstruction of segmental bone defect.Medical & biological engineering & computing · 2022Article
- The advances in nanomedicine for bone and cartilage repair.Journal of nanobiotechnology · 2022Review
- The Synthesis of Hydroxyapatite by Hydrothermal Process with Calcium Lactate Pentahydrate: The Effect of Reagent Concentrations, pH, Temperature, and Pressure.Bioinorganic chemistry and applications · 2022Article
- The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute.Scientific reports · 2020Article
- Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration.Tissue engineering and regenerative medicine · 2020Article
- Effects of treatment with three types of varnish remineralizing agents on the microhardness of demineralized enamel surface.Journal of clinical and experimental dentistry · 2019Article
- Co-Delivery of Teriflunomide and Methotrexate from Hydroxyapatite Nanoparticles for the Treatment of Rheumatoid Arthritis: In Vitro Characterization, Pharmacodynamic and Biochemical Investigations.Pharmaceutical research · 2018Article
- Single-dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical-sized calvarial defect.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Optimized Bone Regeneration in Calvarial Bone Defect Based on Biodegradation-Tailoring Dual-shell Biphasic Bioactive Ceramic Microspheres.Scientific reports · 2018Article
- Diagnostic guidelines for the histological particle algorithm in the periprosthetic neo-synovial tissue.BMC clinical pathology · 2018Article
- Yolk @ cage-Shell Hollow Mesoporous Monodispersion Nanospheres of Amorphous Calcium Phosphate for Drug Delivery with High Loading Capacity.Nanoscale research letters · 2017Article
- Injectable hybrid system for strontium local delivery promotes bone regeneration in a rat critical-sized defect model.Scientific reports · 2017Article
- Template-free synthesis of phosphate-based spheres via modified supersaturated phosphate buffer solutions.Journal of materials science. Materials in medicine · 2017Article
- Microwave-Assisted Hydrothermal Synthesis of Cellulose/Hydroxyapatite Nanocomposites.Polymers · 2016Article
- Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression.Biomaterials · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate materials have been used increasingly in the past 40 years as bone graft substitutes in the dental and orthopedic fields. Accordingly, numerous fabrication methods have been proposed and used. However, the controlled production of spherical calcium phosphate particles remains a challenge. Since such particles are essential for the synthesis of pastes and cements delivered into the host bone by minimally-invasive approaches, the aim of the present document is to review their synthesis and applications. For that purpose, production methods were classified according to the used reagents (solutions, slurries, pastes, powders), dispersion media (gas, liquid, solid), dispersion tools (nozzle, propeller, sieve, mold), particle diameters of the end product (from 10 nm to 10 mm), and calcium phosphate phases. Low-temperature calcium phosphates such as monetite, brushite or octacalcium phosphate, as well as high-temperature calcium phosphates, such as hydroxyapatite, β-tricalcium phosphate or tetracalcium phosphate, were considered. More than a dozen production methods and over hundred scientific publications were discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.