Trial reportNeurology2013
Pretreatment EEG in childhood absence epilepsy: associations with attention and treatment outcome.
Trial report in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- Pretreatment behavior and subsequent medication effects in childhood absence epilepsy.Neurology · 2017Trial
- Pretreatment seizure semiology in childhood absence epilepsy.Neurology · 2017Trial
- Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.Annals of neurology · 2017Trial
- Journal club: pretreatment EEG in childhood absence epilepsy.Neurology · 2014Trial
- Sleep spindle deficits in childhood absence epilepsy improve with antiseizure treatment and disease resolution.bioRxiv : the preprint server for biology · 2026Article
- Article
- Retraining and evaluation of machine learning and deep learning models for seizure classification from EEG data.Scientific reports · 2025Article
- EEG focal delta slowing in focal epilepsy - A didactic review.Clinical neurophysiology practice · 2025Review
- Review
- Long-term Prognosis of Childhood Absence Epilepsy.Noro psikiyatri arsivi · 2024Review
- Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans.Neurobiology of disease · 2022Article
- Clinical and Instrumental Follow-Up of Childhood Absence Epilepsy (CAE): Exploration of Prognostic Factors.Children (Basel, Switzerland) · 2022Article
- An integrative prediction algorithm of drug-refractory epilepsy based on combined clinical-EEG functional connectivity features.Journal of neurology · 2022Article
- Difficult to treat absence seizures in children: A single-center retrospective study.Frontiers in neurology · 2022Article
- Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD.Experimental neurology · 2021Article
- Hyperventilation maneuver during EEG in children with epilepsy after the COVID-19 pandemic. Is a routine procedure necessary?Epilepsia open · 2021Article
- EEG-Driven Prediction Model of Oxcarbazepine Treatment Outcomes in Patients With Newly-Diagnosed Focal Epilepsy.Frontiers in medicine · 2021Article
- Pretreatment Source Location and Functional Connectivity Network Correlated With Therapy Response in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2021Article
- When should we obtain a routine EEG while managing people with epilepsy?Epilepsy & behavior reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveIn children with newly diagnosed childhood absence epilepsy (CAE), determine pretreatment EEG features and their associations with baseline neuropsychological function and short-term treatment outcome.
methodsIn a multicenter, randomized clinical trial, patients with CAE underwent a pretreatment, 1-hour video-EEG and neuropsychological testing with freedom-from-failure and seizure-freedom (SF) outcome assessed at the 16- to 20-week visit.
resultsDetailed evaluation of the pretreatment EEG was possible for 99.8% of participants (445/446). Median time to first seizure was 6.0 minutes (range 0-59 minutes), median number of seizures was 5 (range 1-60), and median seizure duration was 10.8 seconds (range 3.3-77.6 seconds). Median duration of shortest seizure per EEG was 7.5 seconds (range 3.0-77.6 seconds). Seizure frequency was not associated with baseline measures of attention, executive function, or treatment outcome. Presence of a seizure lasting ≥20 seconds was noted in 29% of subjects (129/440); these children had higher median omissions T score on the Conners Continuous Performance Test (56.3 vs 51.6, p = 0.01). Patients with a shortest seizure of longer duration were more likely to demonstrate treatment success by both freedom-from-failure (p = 0.02) and SF (p = 0.005) criteria, even after controlling for age, treatment group, and number of seizures, with good predictive value (area under the curve 78% for SF).
conclusionsCAE is reliably and quickly confirmed by EEG. Occurrence of a seizure ≥20 seconds, but not overall seizure frequency, was associated with differential baseline measures of attention. Patients whose shortest pretreatment EEG seizure was longer in duration were more likely to achieve SF, regardless of treatment.
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