ArticleNeuroreport2013
Serotonin(2C) receptors in the ventral pallidum regulate motor function in rats.
Article in Neuroreport, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
- Activation of Ventral Pallidum CaMKIIa-Expressing Neurons Promotes Wakefulness.Neurochemical research · 2023Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- The antipsychotic drug sulpiride in the ventral pallidum paradoxically impairs learning and induces place preference.Scientific reports · 2022Article
- An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Activation of Ventral Tegmental Area 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors.Progress in neurobiology · 2015Review
- Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT(2C) receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT(2C) receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT(2C) receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT(2C) receptors in the ventral pallidum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.