ArticleBMC evolutionary biology2013
The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Genome-wide identification and expression profiling of the CoVQ gene family in Camellia Oleifera.BMC plant biology · 2026Article
- Androgen-Binding Protein (Abp) Evolutionary History: Has Positive Selection Caused Fixation of Different Paralogs in Different Taxa of the Genus Mus?Genome biology and evolution · 2021Article
- The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality.Genome biology and evolution · 2021Article
- Functional signatures of evolutionarily young CTCF binding sites.BMC biology · 2020Article
- Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera.eLife · 2019Article
- Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2018Article
- Repeat associated mechanisms of genome evolution and function revealed by theGenome research · 2018Article
- Copy number increases of transposable elements and protein-coding genes in an invasive fish of hybrid origin.Molecular ecology · 2017Article
- Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions.Genome biology and evolution · 2017Article
- Detection and validation of structural variations in bovine whole-genome sequence data.Genetics, selection, evolution : GSE · 2017Article
- The Role of Retrotransposons in Gene Family Expansions in the Human and Mouse Genomes.Genome biology and evolution · 2016Article
- Dynamics of copy number variation in host races of the pea aphid.Molecular biology and evolution · 2015Article
- Genome architecture and its roles in human copy number variation.Genomics & informatics · 2014Review
- Genome-wide identification, splicing, and expression analysis of the myosin gene family in maize (Zea mays).Journal of experimental botany · 2014Article
- Did androgen-binding protein paralogs undergo neo- and/or Subfunctionalization as the Abp gene region expanded in the mouse genome?PloS one · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
backgroundRetrotransposons have been suggested to provide a substrate for non-allelic homologous recombination (NAHR) and thereby promote gene family expansion. Their precise role, however, is controversial. Here we ask whether retrotransposons contributed to the recent expansions of the Androgen-binding protein (Abp) gene families that occurred independently in the mouse and rat genomes.
resultsUsing dot plot analysis, we found that the most recent duplication in the Abp region of the mouse genome is flanked by L1Md_T elements. Analysis of the sequence of these elements revealed breakpoints that are the relicts of the recombination that caused the duplication, confirming that the duplication arose as a result of NAHR using L1 elements as substrates. L1 and ERVII retrotransposons are considerably denser in the Abp regions than in one Mb flanking regions, while other repeat types are depleted in the Abp regions compared to flanking regions. L1 retrotransposons preferentially accumulated in the Abp gene regions after lineage separation and roughly followed the pattern of Abp gene expansion. By contrast, the proportion of shared vs. lineage-specific ERVII repeats in the Abp region resembles the rest of the genome.
conclusionsWe confirmed the role of L1 repeats in Abp gene duplication with the identification of recombinant L1Md_T elements at the edges of the most recent mouse Abp gene duplication. High densities of L1 and ERVII repeats were found in the Abp gene region with abrupt transitions at the region boundaries, suggesting that their higher densities are tightly associated with Abp gene duplication. We observed that the major accumulation of L1 elements occurred after the split of the mouse and rat lineages and that there is a striking overlap between the timing of L1 accumulation and expansion of the Abp gene family in the mouse genome. Establishing a link between the accumulation of L1 elements and the expansion of the Abp gene family and identification of an NAHR-related breakpoint in the most recent duplication are the main contributions of our study.
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