ArticleJournal of nanobiotechnology2013
Folic acid-conjugated silica capped gold nanoclusters for targeted fluorescence/X-ray computed tomography imaging.
Article in Journal of nanobiotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 100 citations in OpenAlex.
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- Precious metal clusters as fundamental agents in bioimaging usability.Frontiers in chemistry · 2023Review
- Advances of gold nanoclusters for bioimaging.iScience · 2022Review
- Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer.Journal of nanobiotechnology · 2022Review
- Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.Biosensors · 2022Review
- Enriched Au nanoclusters with mesoporous silica nanoparticles for improved fluorescence/computed tomography dual-modal imaging.Cell proliferation · 2021Article
- The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer.Frontiers in oncology · 2021Review
- Plant-derived silica nanoparticles and composites for biosensors, bioimaging, drug delivery and supercapacitors: a review.Environmental chemistry letters · 2021Review
- In vivo evaluation of CD38 and CD138 as targets for nanoparticle-based drug delivery in multiple myeloma.Journal of hematology & oncology · 2020Article
- Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer.Journal of nanobiotechnology · 2020Article
- Nanoparticles in Gastrooncology.Visceral medicine · 2020Review
- Surface modification of plasmonic noble metal-metal oxide core-shell nanoparticles.Nanoscale advances · 2019Review
- Gastric Parietal Cell and Intestinal Goblet Cell Secretion: a Novel Cell-Mediated In Vivo Metal Nanoparticle Metabolic Pathway Enhanced with Diarrhea Via Chinese Herbs.Nanoscale research letters · 2019Article
- Diverse Applications of Nanomedicine.ACS nano · 2017Review
- Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes.Contrast media & molecular imaging · 2017Review
- Superparamagnetic FeScientific reports · 2016Article
- Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA.Scientific reports · 2015Article
- Facile synthesis of fluorescent Au/Ce nanoclusters for high-sensitive bioimaging.Journal of nanobiotechnology · 2015Article
- Nanoparticles for multimodal in vivo imaging in nanomedicine.International journal of nanomedicine · 2014Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer is 2th most common cancer in China, and is still the second most common cause of cancer-related death in the world. Successful development of safe and effective nanoprobes for in vivo gastric cancer targeting imaging is a big challenge. This study is aimed to develop folic acid (FA)-conjugated silica coated gold nanoclusters (AuNCs) for targeted dual-modal fluorescent and X-ray computed tomography imaging (CT) of in vivo gastric cancer cells.
methodAuNCs were prepared, silica was coated on the surface of AuNCs, then folic acid was covalently anchored on the surface of AuNCs, resultant FA-conjugated AuNCs@SiO2 nanoprobes were investigated their cytotoxicity by MTT method, and their targeted ability to FR(+) MGC803 cells and FR(-) GES-1 cells. Nude mice model loaded with MGC803 cells were prepared, prepared nanoprobes were injected into nude mice via tail vein, and then were imaged by fluorescent and X-ray computed tomography (CT) imaging.
resultsFA-conjugated AuNCs@SiO2 nanoprobes exhibited good biocompatibility, and could target actively the FR(+) MGC-803 cells and in vivo gastric cancer tissues with 5 mm in diameter in nude mice models, exhibited excellent red emitting fluorescence imaging and CT imaging.
conclusionThe high-performance FA-conjugated AuNCs@SiO2 nanoprobes can target in vivo gastric cancer cells, can be used for fluorescent and CT dual-mode imaging, and may own great potential in applications such as targeted dual-mode imaging of in vivo early gastric cancer and other tumors with FR positive expression in near future.
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