ArticleJournal of ophthalmic inflammation and infection2013
Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases.
Article in Journal of ophthalmic inflammation and infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02865876 (Effectiveness of Corneal Accelerated Crosslinking Versus Conventional Treatment for Infectious Keratitis), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Corneal Accelerated Crosslinking Versus Conventional Treatment for Infectious Keratitis
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Photoactivated chromophore-corneal cross-linking accelerates corneal healing in fungal keratitis: an updated meta-analysis.Systematic reviews · 2023Pooled it
- Corneal collagen cross-linking for bacterial infectious keratitis.The Cochrane database of systematic reviews · 2020Pooled it
- Cross-Linking-Assisted Infection Reduction: A Randomized Clinical Trial Evaluating the Effect of Adjuvant Cross-Linking on Outcomes in Fungal Keratitis.Ophthalmology · 2020Trial
- The Significance of Repeat Cultures in the Treatment of Severe Fungal Keratitis.American journal of ophthalmology · 2018Trial
- What We Can Do in Infectious Keratitis, Except for Conventional Antimicrobial-Based Therapies: Major Narrative Review.Health science reports · 2026Article
- Cross-Linked Carboxymethyl Cellulose and Silk Proteins in Corneal Re-Epithelialization: A Case Series.Journal of clinical medicine · 2025Article
- Steroids and Cross-Linking for Ulcer Treatment: The SCUT II Randomized Clinical Trial.JAMA ophthalmology · 2025Article
- Visual outcomes and corneal biomechanical evaluation between LASIK and LASIK combined with accelerated corneal crosslinking.International journal of ophthalmology · 2025Article
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- Collagen cross-linking as monotherapy in experimentally induced corneal abscess in rabbits.BMC ophthalmology · 2023Article
- Photoactivated Chromophore Corneal Collagen Cross-Linking for Infectious Keratitis (PACK-CXL)-A Comprehensive Review of Diagnostic and Prognostic Factors Involved in Therapeutic Indications and Contraindications.Journal of personalized medicine · 2022Review
- Double-masked, sham and placebo-controlled trial of corneal cross-linking and topical difluprednate in the treatment of bacterial keratitis: Steroids and Cross-linking for Ulcer Treatment Trial (SCUT II) study protocol.BMJ open ophthalmology · 2021Article
- Photobiomodulation of the Visual System and Human Health.International journal of molecular sciences · 2020Review
- Accelerated corneal collagen cross-linking in clinical management of infectious keratitis.The Journal of international medical research · 2020Article
- Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Collagen crosslinking with photoactivated riboflavin in advanced infectious keratitis with corneal melting: Electrophysiological Study.International journal of ophthalmology · 2020Article
- Rose Bengal Photodynamic Antimicrobial Therapy for Patients With Progressive Infectious Keratitis: A Pilot Clinical Study.American journal of ophthalmology · 2019Article
- Commentary: PACK-CXL in fungal keratitis.Indian journal of ophthalmology · 2019Article
- Long-term outcomes of riboflavin photodynamic antimicrobial therapy as a treatment for infectious keratitis.American journal of ophthalmology case reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCollagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. The aim of this study is to summarize the previously published data and evaluate the effectiveness of this treatment.
resultsThe search identified 12 articles. The number of eyes was 104. The infectious keratitis was associated with bacteria in 58 eyes (57f%): Gram-positive bacteria in 44 (43%; 4 of which were infected with Mycobacterium (3.6%)) and Gram-negative bacteria in 14 eyes (13%), fungus in 13 eyes (12%), and Acanthamoeba in 7 eyes (7%). In 26 eyes (25%), the microbiological culture was negative or not performed. The mean time of re-epithelization after CXL was 20.7±28.1 days (minimum of 3, maximum of 145). Sixteen eyes underwent deep or lamellar keratoplasty. The pooled analysis suggested that CXL has a favorable effect on the block of corneal melting in 85% (95%; CI 0.77, 0.91) of eyes.
conclusionAlthough randomized controlled trials are needed, the available evidence supports the use of CXL in the treatment of infectious keratitis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.