ArticleAnalytical chemistry2013
Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 148 citations in OpenAlex.
- Emerging Plasmonic Nanomaterials for SERS-Based Disease Diagnostics: Innovations, Clinical Challenges, and AI Integration.Molecules (Basel, Switzerland) · 2026Review
- Advancements in SERS: Revolutionizing Biomedical Analysis and Applications.Nanotheranostics · 2025Review
- Nanoplasmonics biosensors: At the frontiers of biomedical diagnostics.Trends in analytical chemistry : TRAC · 2024Article
- miRNA probe integrated biosensor platform using bimetallic nanostars for amplification-free multiplexed detection of circulating colorectal cancer biomarkers in clinical samples.Biosensors & bioelectronics · 2023Article
- Ion-exchanged glass microrods as hybrid SERS/fluorescence substrates for molecular beacon-based DNA detection.Analytical and bioanalytical chemistry · 2021Article
- A SERS Study of Charge Transfer Process in Au Nanorod-MBA@CuNanomaterials (Basel, Switzerland) · 2021Article
- Surface dynamics of genomic DNAs upon lowering the pH, in the presence of graphene/AgNPs-based SERS detection platform.Journal of molecular modeling · 2020Article
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Label-Free Detection ofSensors (Basel, Switzerland) · 2019Article
- Surface Enhanced Raman Spectroscopy for DNA Biosensors-How Far Are We?Molecules (Basel, Switzerland) · 2019Review
- A Review on Surface-Enhanced Raman Scattering.Biosensors · 2019Review
- Plasmonic nanomaterial structuring for SERS enhancement.RSC advances · 2019Article
- Surface-Enhanced Raman Scattering Spectroscopy and Microfluidics: Towards Ultrasensitive Label-Free Sensing.Biosensors · 2018Review
- Simple, Low-Cost Fabrication of Highly Uniform and Reproducible SERS Substrates Composed of Ag⁻Pt Nanoparticles.Nanomaterials (Basel, Switzerland) · 2018Article
- Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles.Scientific reports · 2018Article
- Plasmonic molecular assays: Recent advances and applications for mobile health.Nano research · 2018Review
- Shining Gold Nanostars: From Cancer Diagnostics to Photothermal Treatment and Immunotherapy.Journal of immunological sciences · 2018Article
- Squamous Cell Carcinoma DNA Detection Using Ultrabright SERS Nanorattles and Magnetic Beads for Head and Neck Cancer Molecular Diagnostics.Analytical methods : advancing methods and applications · 2017Article
- Controllable Charge Transfer in Ag-TiO₂ Composite Structure for SERS Application.Nanomaterials (Basel, Switzerland) · 2017Article
- Sensitive DNA detection and SNP discrimination using ultrabright SERS nanorattles and magnetic beads for malaria diagnostics.Biosensors & bioelectronics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Development of a rapid, cost-effective, label-free biosensor for DNA detection is important for many applications in clinical diagnosis, homeland defense, and environment monitoring. A unique label-free DNA biosensor based on Molecular Sentinel (MS) immobilized on a plasmonic 'Nanowave' chip, which is also referred to as a metal film over nanosphere (MFON), is presented. Its sensing mechanism is based upon the decrease of the surface-enhanced Raman scattering (SERS) intensity when Raman label tagged at one end of MS is physically separated from the MFON's surface upon DNA hybridization. This method is label-free as the target does not have to be labeled. The MFON fabrication is relatively simple and low-cost with high reproducibility based on depositing a thin shell of gold over close-packed arrays of nanospheres. The sensing process involves a single hybridization step between the DNA target sequences and the complementary MS probes on the Nanowave chip without requiring secondary hybridization or posthybridization washing, thus resulting in rapid assay time and low reagent usage. The usefulness and potential application of the biosensor for medical diagnostics is demonstrated by detecting the human radical S-adenosyl methionine domain containing 2 (RSAD2) gene, a common inflammation biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.