ArticleJournal of experimental & clinical cancer research : CR2013
MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b.
Article in Journal of experimental & clinical cancer research : CR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer.Current issues in molecular biology · 2025Review
- Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.International journal of molecular sciences · 2024Article
- Inhibition ofTranslational lung cancer research · 2023Article
- Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer.Oncology letters · 2021Review
- Circulating miRNAs in Serum as Biomarkers for Early Diagnosis of Non-small Cell Lung Cancer.Frontiers in genetics · 2021Article
- Hesperidin administration suppresses the proliferation of lung cancer cells by promoting apoptosis via targeting the miR‑132/ZEB2 signalling pathway.International journal of molecular medicine · 2020Article
- Sex Hormone-Dependent Physiology and Diseases of Liver.International journal of environmental research and public health · 2020Review
- Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cells.Experimental and therapeutic medicine · 2019Article
- An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer.Oncotarget · 2017Article
- The trophoblast cell surface antigen 2 and miR-125b axis in urothelial bladder cancer.Oncotarget · 2017Article
- Ascites promotes cell migration through the repression of miR-125b in ovarian cancer.Oncotarget · 2017Article
- microRNA-664 enhances proliferation, migration and invasion of lung cancer cells.Experimental and therapeutic medicine · 2017Article
- Review
- MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.Scientific reports · 2016Article
- Article
- MTA1 promotes metastasis of MPM via suppression of E-cadherin.Journal of experimental & clinical cancer research : CR · 2015Article
- Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.The Journal of biological chemistry · 2015Article
- Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis.Journal of experimental & clinical cancer research : CR · 2015Article
- miR-96 suppresses renal cell carcinoma invasion via downregulation of Ezrin expression.Journal of experimental & clinical cancer research : CR · 2015Article
- MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN.Journal of experimental & clinical cancer research : CR · 2015Article
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9 authors.
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Abstract
backgroundThe metastasis-associated gene 1 (MTA1) has been identified as one critical regulator of tumor metastasis. Previously, we identified miR-125b as a downregualted miRNA in non-small cell lung cancer (NSCLC) cell line upon MTA1 depletion. However, the role of miR-125b and MTA1 in the regulation of NSCLC metastasis remains unclear.
methodsStable MTA1 knockdown NSCLC cell lines 95D and SPC-A-1 were established by transfection with MTA1 shRNA. The effects of MTA1 depletion on the expression of miR-125b and cell migration and invasion were examined by real-time PCR, wound healing and matrigel invasion assay.
resultsMTA1 knockdown led to the upregulation of miR-125b level in NSCLC cells. Furthermore, MTA1 knockdown reduced while miR-125b inhibitor enhanced cell migration and invasion of NSCLC cells. Notably, miR-125b inhibitor antagonized MTA1 siRNA induced inhibition of cell migration and invasion.
conclusionMTA1 and miR-125b have antagonistic effects on the migration and invasion of NSCLC cells. The newly identified MTA1-miR-125b axis will help further elucidate the molecular mechanism of NSCLC progression and suggest that ectopic expression of miR-125b is a potentially new therapeutic regimen against NSCLC metastasis.
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