Evidence map›Paper›PMID 23718251›Full record

ArticleBMC microbiology2013

Cytotoxicity and inflammatory potential of two Pseudomonas mosselii strains isolated from clinical samples of hospitalized patients.

Charlène Leneveu-Jenvrin, Amar Madi, Emeline Bouffartigues, Kelly Biaggini, Marc Feuilloley, Sylvie Chevalier, Nathalie Connil

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  6. Zinc Exposure Promotes Commensal-to-Pathogen Transition inInternational journal of molecular sciences · 2021
    Article
  7. Frontiers in microbiology · 2019
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charlène Leneveu-JenvrinLaboratoire de Microbiologie Signaux et Microenvironnement-LMSM EA 4312, Université de Rouen, Normandie Université, 55 Rue Saint-Germain, Evreux F-27000, France.
Amar Madi
Emeline Bouffartigues
Kelly Biaggini
Marc Feuilloley
Sylvie Chevalier
Nathalie Connil
Normandie Université · FRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genus Pseudomonas includes a heterogeneous set of microorganisms that can be isolated from many different niches and nearly 100 different strains have been described. The best characterized bacterium is Pseudomonas aeruginosa which is the primary agent of opportunistic infection in humans, causing both acute and chronic infections. Other species like fluorescens, putida or mosselii have been sporadically isolated from hospitalized patients but their association with the pathology often remains unclear.

resultsThis study focuses on the cytotoxicity and inflammatory potential of two strains of Pseudomonas mosselii (ATCC BAA-99 and MFY161) that were recently isolated from clinical samples of hospitalized patients. The behavior of these bacteria was compared to that of the well-known opportunistic pathogen P. aeruginosa PAO1. We found that P. mosselii ATCC BAA-99 and MFY161 are cytotoxic towards Caco-2/TC7 cells, have low invasive capacity, induce secretion of human β-defensin 2 (HBD-2), alter the epithelial permeability of differentiated cells and damage the F-actin cytoskeleton.

conclusionsThese data bring new insights into P. mosselii virulence, since this bacterium has often been neglected due to its rare occurrence in hospital.

Indexed as

ActinsBacterial Toxinsbeta-DefensinsCell LineCell Membrane PermeabilityEndocytosisEpithelial CellsHospitalsHumansPseudomonasPseudomonas InfectionsVirulenceActinsBacterial Toxinsbeta-DefensinsDEFB4A protein, human

Identifiers

PMID23718251
PMCPMC3679952
OpenAlexW2060159535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.