ArticleBMC genomics2013
Quantitative trait loci in hop (Humulus lupulus L.) reveal complex genetic architecture underlying variation in sex, yield and cone chemistry.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Association mapping for hop cone chemistry and morphology identifies natural beneficial allele stacks.The plant genome · 2026Article
- Extensive variation between chromosomes of North American and European hop.Nature communications · 2026Article
- Genetic components associated with R2 and R4 powdery mildew resistance in hop.The plant genome · 2026Article
- Dynamic patterns of repeats and retrotransposons in the centromeres of Humulus lupulus L.The New phytologist · 2025Article
- Analysis of chemical and genetic variability in wild hop (Humulus lupulus L.) populations of Kosovo.Plant biology (Stuttgart, Germany) · 2025Article
- An affordable and convenient diagnostic marker to identify male and female hop plants.G3 (Bethesda, Md.) · 2023Article
- Stepwise Targeted Matching Strategy for Comprehensive Profiling of Xanthohumol Metabolites In Vivo and In Vitro Using UHPLC-Q-Exactive Orbitrap Mass Spectrometer.Molecules (Basel, Switzerland) · 2023Article
- Construction of the first high-density genetic linkage map and QTL mapping of flavonoid and leaf-size related traits in Epimedium.BMC plant biology · 2023Article
- Performance of Hop Cultivars Grown with Artificial Lighting under Subtropical Conditions.Plants (Basel, Switzerland) · 2023Article
- Portuguese wild hop diversity assessment by fast SNP genotyping using high-resolution melting.Journal of applied genetics · 2022Article
- Two fingerprinting sets for Humulus lupulus based on KASP and microsatellite markers.PloS one · 2022Article
- The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway.Frontiers in oncology · 2022Article
- Hop Polyphenols in Relation to Verticillium Wilt Resistance and Their Antifungal Activity.Plants (Basel, Switzerland) · 2020Article
- New Male Specific Markers for Hop and Application in Breeding Program.Scientific reports · 2019Article
- The molecular biology of fruity and floral aromas in beer and other alcoholic beverages.FEMS microbiology reviews · 2019Review
- Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in vitro.Oncology reports · 2018Article
- Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Frontiers in pharmacology · 2018Review
- 3D Molecular Cytology of Hop (Frontiers in plant science · 2018Article
- The genetic architecture of growth traits inHorticulture research · 2017Article
- Genomic approaches to selection in outcrossing perennials: focus on essential oil crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Review
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Authors and funding
17 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHop (Humulus lupulus L.) is cultivated for its cones, the secondary metabolites of which contribute bitterness, flavour and aroma to beer. Molecular breeding methods, such as marker assisted selection (MAS), have great potential for improving the efficiency of hop breeding. The success of MAS is reliant on the identification of reliable marker-trait associations. This study used quantitative trait loci (QTL) analysis to identify marker-trait associations for hop, focusing on traits related to expediting plant sex identification, increasing yield capacity and improving bittering, flavour and aroma chemistry.
resultsQTL analysis was performed on two new linkage maps incorporating transferable Diversity Arrays Technology (DArT) markers. Sixty-three QTL were identified, influencing 36 of the 50 traits examined. A putative sex-linked marker was validated in a different pedigree, confirming the potential of this marker as a screening tool in hop breeding programs. An ontogenetically stable QTL was identified for the yield trait dry cone weight; and a QTL was identified for essential oil content, which verified the genetic basis for variation in secondary metabolite accumulation in hop cones. A total of 60 QTL were identified for 33 secondary metabolite traits. Of these, 51 were pleiotropic/linked, affecting a substantial number of secondary metabolites; nine were specific to individual secondary metabolites.
conclusionsPleiotropy and linkage, found for the first time to influence multiple hop secondary metabolites, have important implications for molecular selection methods. The selection of particular secondary metabolite profiles using pleiotropic/linked QTL will be challenging because of the difficulty of selecting for specific traits without adversely changing others. QTL specific to individual secondary metabolites, however, offer unequalled value to selection programs. In addition to their potential for selection, the QTL identified in this study advance our understanding of the genetic control of traits of current economic and breeding significance in hop and demonstrate the complex genetic architecture underlying variation in these traits. The linkage information obtained in this study, based on transferable markers, can be used to facilitate the validation of QTL, crucial to the success of MAS.
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