ArticlePloS one2013
Systemic inflammation is associated with ovarian follicular dynamics during the human menstrual cycle.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Does Lifelong Exercise Counteract Low-Grade Inflammation Associated with Aging? A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women.Fertility and sterility · 2018Trial
- Menstrual vulnerability to acute systemic stress: evidence from 884 women after COVID-19 infection.BMC women's health · 2026Article
- Increased C-Reactive Protein Concentrations During Menstruation May Be Important for the Pathophysiology of Endometriosis and Possibly for Adhesion Formation-A Systematic Review.Journal of clinical medicine · 2026Review
- Inflammation and Ovarian Function in Reproductive-Aged Women.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Neuregulin 1 Signaling Attenuates Tumor Necrosis Factor α-Induced Female Rat Luteal Cell Death.Endocrinology · 2024Article
- Systemic inflammation and menstrual cycle length in a prospective cohort study.American journal of obstetrics and gynecology · 2023Article
- Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response.Brain, behavior, & immunity - health · 2022Article
- Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell.Journal of ovarian research · 2022Article
- Interrelationship between reproductive hormones and acute phase proteins during estrous cycle and pregnancy in Spanish purebred broodmares.Veterinary and animal science · 2021Article
- Oxygen saturation during sleep as a predictor of inflammation in anovulatory women.Sleep & breathing = Schlaf & Atmung · 2021Article
- Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women.European journal of applied physiology · 2021Article
- Inflammation and reproductive function in women with polycystic ovary syndrome†.Biology of reproduction · 2021Review
- Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar.Frontiers in cellular and infection microbiology · 2021Article
- Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis.Frontiers in endocrinology · 2018Article
- Race disparities in pubertal timing: Implications for cardiovascular disease risk among African American women.Population research and policy review · 2017Article
- Normobaric hypoxia overnight impairs cognitive reaction time.BMC neuroscience · 2017Article
- Energetics and the immune system: Trade-offs associated with non-acute levels of CRP in adolescent Gambian girls.Evolution, medicine, and public health · 2017Article
- Article
- Early developmental exposures shape trade-offs between acquired and innate immunity in humans.Evolution, medicine, and public health · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundOvarian processes and the timing of ovulation are important predictors of both female fertility and reproductive pathology. Multiple waves of antral follicular development have been documented during the menstrual cycle in women. However, the mechanisms underlying the development of follicular waves and their clinical significance are not fully understood. The objective of this study was to examine the relationship between C-reactive protein (CRP) and follicular waves in healthy women. We wanted to determine whether follicular wave dynamics influence systemic inflammation, as ovarian activity increases local inflammatory processes and blood flow. We tested the hypothesis that women with 3 follicular waves would have higher CRP concentrations than those with 2 waves. We further hypothesized that a greater number of major waves (those with a dominant follicle) would be positively associated with CRP. METHODS/PRINCIPAL
findingsThirty-nine healthy women underwent daily transvaginal ultrasound examinations for one interovulatory interval, as part of an earlier study. Serum was collected every 3 days during the interovulatory interval (IOI). Enzyme-linked immunosorbent assays were conducted to quantify serum CRP concentrations. Women with 3 waves had higher average log CRP concentrations (n = 14, -0.43±0.35) over the IOI than those with 2 waves (n = 25, -0.82±0.47, p = 02). Average log CRP concentrations were greater in women with 3 (0.30±0.31) versus 1 (-0.71±0.55) or 2 (-0.91±0.47) major waves (p = 0.03). Greater average CRP over the IOI was attributed to greater CRP in the follicular, but not the luteal phase, of the IOI. CONCLUSIONS/SIGNIFICANCE: A greater number of total antral follicular waves, in particular major waves, corresponded to greater serum concentrations of CRP. These findings suggest that women with a greater number of follicular waves exhibit greater tissue remodeling and therefore greater local and systemic inflammation.
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Registered trials
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