ArticlePloS one2013
Janus kinase 2 polymorphisms are associated with risk in patients with gastric cancer in a Chinese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Association between hOGG1 polymorphism rs1052133 and gastric cancer.Oncotarget · 2017Pooled it
- Molecular landscape of theBiomedical reports · 2023Article
- SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.Oncotarget · 2020Article
- Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population.Oncotarget · 2016Article
- The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population.Oncotarget · 2016Article
- Association analysis ofOncoTargets and therapy · 2016Article
- Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population.Oncotarget · 2015Article
- Polymorphisms in immune mediators associate with risk of cervical cancer.Gynecologic oncology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the impact of the Janus kinase 2 single nucleotide polymorphisms (SNPs) on gastric cancer risk.
methodsIn this hospital-based, case-control study, the genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism protocols in 661 individuals (359 gastric cancer patients and 302 age and sex matched cancer-free controls).
resultsBoth the frequency of A allele in rs2230724 and G allele in rs1887427 were more frequent in patients with gastric cancer (P = 0.013 and 0.001, respectively). Compared with the common genotype, subjects with the (AG+AA) genotypes of rs2230724 and the (AG+GG) genotypes of rs1887427 had a 59% and 98% increased risk of developing gastric cancer, respectively (P = 0.010, adjusted OR = 1.59, 95% CI = 1.12-2.27; P<0.001, adjusted OR = 1.98, 95% CI = 1.39-2.81, respectively). Further stratified analysis showed that the association between the risk of gastric cancer and the rare genotypes of rs2230724 were more profound in the subgroups of elder individuals (>56 years), males, nonsmokers and urban subjects, while the association between the risk and the rare genotypes of rs1887427 persisted in subgroups of younger individuals (≤56 years), males, nonsmokers and both of rural and urban subjects.
conclusionThe JAK2 gene rs2230724 and rs1887427 polymorphisms are associated with an increased risk of gastric cancer in a Chinese Han population.
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