ArticlePloS one2013
Augmenting transport versus increasing cold storage to improve vaccine supply chains.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Determinants of effective vaccine coverage in low and middle-income countries: a systematic review and interpretive synthesis.BMC health services research · 2017Pooled it
- Optimizing the COVID-19 cold chain vaccine distribution network with medical waste management: A robust optimization approach.Expert systems with applications · 2023Article
- When increasing vegetable production may worsen food availability gaps: A simulation model in India.Food policy · 2023Article
- Vaccination process evaluation at COVID-19 vaccination centers in Lebanon: a national study.Journal of pharmaceutical policy and practice · 2022Article
- A Perspective on Implementation Outcomes and Strategies to Promote the Uptake of COVID-19 Vaccines.Frontiers in health services · 2022Article
- Resource allocation for different types of vaccines against COVID-19: Tradeoffs and synergies between efficacy and reach.Vaccine · 2021Article
- A systems map of the economic considerations for vaccination: Application to hard-to-reach populations.Vaccine · 2021Article
- A novel bi-objective model of cold chain logistics considering location-routing decision and environmental effects.PloS one · 2020Article
- Article
- Economic impact of thermostable vaccines.Vaccine · 2017Article
- Operations research in global health: a scoping review with a focus on the themes of health equity and impact.Health research policy and systems · 2017Article
- [Effectiveness of vaccine management and quality of immunization services in the Expanded Programme on Immunization (EPI) antenna in the Kisangani region, Democratic Republic of Congo].The Pan African medical journal · 2017Article
- Article
- Article
- The impact of implementing a demand forecasting system into a low-income country's supply chain.Vaccine · 2016Article
- Modular vaccine packaging increases packing efficiency.Vaccine · 2015Article
- Economics and financing of vaccines for diarrheal diseases.Human vaccines & immunotherapeutics · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
Abstract
backgroundWhen addressing the urgent task of improving vaccine supply chains, especially to accommodate the introduction of new vaccines, there is often a heavy emphasis on stationary storage. Currently, donations to vaccine supply chains occur largely in the form of storage equipment.
methodsThis study utilized a HERMES-generated detailed, dynamic, discrete event simulation model of the Niger vaccine supply chain to compare the impacts on vaccine availability of adding stationary cold storage versus transport capacity at different levels and to determine whether adding stationary storage capacity alone would be enough to relieve potential bottlenecks when pneumococcal and rotavirus vaccines are introduced by 2015.
resultsRelieving regional level storage bottlenecks increased vaccine availability (by 4%) more than relieving storage bottlenecks at the district (1% increase), central (no change), and clinic (no change) levels alone. Increasing transport frequency (or capacity) yielded far greater gains (e.g., 15% increase in vaccine availability when doubling transport frequency to the district level and 18% when tripling). In fact, relieving all stationary storage constraints could only increase vaccine availability by 11%, whereas doubling the transport frequency throughout the system led to a 26% increase and tripling the frequency led to a 30% increase. Increasing transport frequency also reduced the amount of stationary storage space needed in the supply chain. The supply chain required an additional 61,269L of storage to relieve constraints with the current transport frequency, 55,255L with transport frequency doubled, and 51,791L with transport frequency tripled.
conclusionsWhen evaluating vaccine supply chains, it is important to understand the interplay between stationary storage and transport. The HERMES-generated dynamic simulation model showed how augmenting transport can result in greater gains than only augmenting stationary storage and can reduce stationary storage needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.