ArticlePloS one2013
Anatomical correlates of cognitive functions in early Parkinson's disease patients.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
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- Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance.Scientific reports · 2019Trial
- Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.Brain imaging and behavior · 2017Trial
- Hippocampal atrophy in untreated de novo Parkinson's disease with obstructive sleep apnea.NPJ Parkinson's disease · 2026Article
- Association of Preoperative Linear MRI Measures with Domain-Specific Cognitive Change After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.Journal of clinical medicine · 2025Article
- A multimodal MRI framework employing machine learning for detecting beginning cognitive impairment in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Neuronal threshold functions: Determining symptom onset in neurological disorders.Progress in neurobiology · 2024Review
- Addenbrooke's cognitive examination III: diagnostic utility for detecting mild cognitive impairment and dementia in Parkinson's disease.Arquivos de neuro-psiquiatria · 2023Observational
- Cerebral cortical thickness and cognitive decline in Parkinson's disease.Cerebral cortex communications · 2023Article
- Association between brain structures and migraine: A bidirectional Mendelian randomization study.Frontiers in neuroscience · 2023Article
- The structural changes of gray matter in Parkinson disease patients with mild cognitive impairments.PloS one · 2022Article
- The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease.Brain structure & function · 2021Article
- Neuroanatomical changes in early Parkinson's disease with mild cognitive impairment: a VBM study; the Parkinson's Disease Cognitive Impairment Study (PaCoS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Quantification of Brain β-Amyloid Load in Parkinson's Disease With Mild Cognitive Impairment: A PET/MRI Study.Frontiers in neurology · 2021Article
- Biomarkers for Dementia, Fatigue, and Depression in Parkinson's Disease.Frontiers in neurology · 2019Review
- Connectivity Between Brain Networks Dynamically Reflects Cognitive Status of Parkinson's Disease: A Longitudinal Study.Journal of Alzheimer's disease : JAD · 2019Article
- Objective and automatic classification of Parkinson disease with Leap Motion controller.Biomedical engineering online · 2018Article
- Cerebellar Volume and Executive Function in Parkinson Disease with and without Freezing of Gait.Journal of Parkinson's disease · 2017Article
- Gray matter correlates of dopaminergic degeneration in Parkinson's disease: A hybrid PET/MR study using (18) F-FP-CIT.Human brain mapping · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alterations in patients with early stage PD and its relationship with cognitive disability.
methodsWe recruited 29 PD patients and 21 healthy controls. All PD patients performed an extensive neuropsychological examination and 14 were diagnosed with mild cognitive impairment (PD-MCI). Surface-based cortical thickness analysis was applied to investigate the topographical distribution of cortical and subcortical alterations in early PD compared with controls and to assess the relationship between cognition and regional cortical changes in PD-MCI.
resultsOverall PD patients showed focal cortical (occipital-parietal areas, orbito-frontal and olfactory areas) and subcortical thinning when compared with controls. PD-MCI showed a wide spectrum of cognitive deficits and related significant regional thickening in the right parietal-frontal as well as in the left temporal-occipital areas.
conclusionOur results confirm the presence of changes in grey matter thickness at relatively early PD stage and support previous studies showing thinning and atrophy in the neocortex and subcortical regions. Relative cortical thickening in PD-MCI may instead express compensatory neuroplasticity. Brain reserve mechanisms might first modulate cognitive decline during the initial stages of PD.
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