ArticlePloS one2013
Activated eosinophils in association with enteric nerves in inflammatory bowel disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Rediscovering eosinophil identity through tissue adaptation.Nature immunology · 2026Review
- Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026Review
- Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease.Journal of leukocyte biology · 2026Article
- Winnie Mice: A Chronic and Progressive Model of Ulcerative Colitis.Inflammatory bowel diseases · 2025Review
- Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease.Nature reviews. Immunology · 2024Review
- Rationale for an Eosinophilic Esophagitis Treat-to-Target Concept.Gastroenterology & hepatology · 2024Article
- Eosinophils, Eosinophilic Gastrointestinal Diseases, and Inflammatory Bowel Disease: A Critical Review.Journal of clinical medicine · 2024Review
- Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in theInternational journal of molecular sciences · 2022Article
- Review
- The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice.The Journal of experimental medicine · 2022Article
- Review
- Neurokinin receptors and their implications in various autoimmune diseases.Current research in immunology · 2021Review
- Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond.Advances in experimental medicine and biology · 2021Review
- Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration in inflammatory bowel disease in murine models.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship.Cells · 2020Article
- The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease.Immune network · 2020Review
- Outcomes of inflammatory bowel disease in patients with eosinophil-predominant colonic inflammation.BMJ open gastroenterology · 2020Article
- Role of mast cells and eosinophils in different stages of trinitrobenzenosulphonic acid-induced rat colitis.International journal of clinical and experimental pathology · 2019Article
- Assessment of eosinophils in gastrointestinal inflammatory disease of dogs.Journal of veterinary internal medicine · 2018Article
- A key requirement for CD300f in innate immune responses of eosinophils in colitis.Mucosal immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Enteric neural dysfunction leads to increased mucous production and dysmotility in inflammatory bowel disease (IBD). Prior studies have shown that tissue eosinophilia is related to disease activity. We hypothesized that interactions between eosinophils and nerves contribute to neural dysfunction in IBD. Tissue from patients with intractable IBD, endoscopic biopsies from patients with steroid responsive IBD, both when active and quiescent, and control tissue were studied. Immunohistochemical studies showed that eosinophils localize to nerves in the mucosal layer of patients with Crohn's disease (CD) (p<0.001) and ulcerative colitis (UC), (p<0.01). Eosinophils localized to substance P and choline acetyltransferase (ChAT) immunostained nerves. Real time PCR of laser capture micro-dissected enteric ganglia demonstrated Intercellular Adhesion Molecule 1 (ICAM-1) mRNA was increased 7-fold in UC (n = 4), (p = 0.03), and 10-fold in CD (n = 3), (p = 0.05). Compared with controls, eotaxin-3 (CCL-26) mRNA was increased 9-fold in UC (p = 0.04) and 15-fold in CD (p = 0.06). Eosinophil numbers correlated with disease activity, while deposition of major basic protein (MBP) and eosinophil Transforming Growth Factor β-1 (TGFβ-1) expression were seen in therapeutically responsive disease. These data indicate a significant localization of eosinophils to nerves in IBD, mediated through neurally expressed ICAM-1 and eotaxin-3. This cell/neural interaction may influence the function of nerves and contribute to symptoms in IBD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.