ArticlePloS one2013
Global gene expression profiling of individual human oocytes and embryos demonstrates heterogeneity in early development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Discordant effects of maternal age on the human MII oocyte transcriptome.Molecular human reproduction · 2025Article
- Deciphering differences in DNA methylation and transcriptome profiles of oocytes from pigs with high and low developmental competence.Environmental epigenetics · 2025Article
- Runs of homozygosity and signatures of selection for number of oocytes and embryos in the Gir Indicine cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Transcriptomic and Proteomic Analyses of Celery Cytoplasmic Male Sterile Line and Its Maintainer Line.International journal of molecular sciences · 2023Article
- Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.Frontiers in molecular biosciences · 2023Article
- The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.Human reproduction (Oxford, England) · 2021Article
- Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.Scientific reports · 2021Article
- The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cellsHuman reproduction open · 2020Article
- Systems based analysis of human embryos and gene networks involved in cell lineage allocation.BMC genomics · 2019Article
- Single-cell transcriptome sequencing reveals that cell division cycle 5-like protein is essential for porcine oocyte maturation.The Journal of biological chemistry · 2018Article
- Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development.BioMed research international · 2018Article
- Global gene expression profiling and senescence biomarker analysis of hESC exposed to HStem cell research & therapy · 2017Article
- Comprehensive chromosome screening and gene expression analysis from the same biopsy in human preimplantation embryos.Molecular human reproduction · 2017Article
- Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss.Proteomics. Clinical applications · 2016Article
- Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.Stem cells and development · 2016Article
- Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.Nature communications · 2015Article
- Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression.Fertility and sterility · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from assisted reproduction programmes provides additional evidence that this is largely mediated at the level of embryonic competence and is highly heterogeneous among embryos. Understanding the basis of this heterogeneity has important implications in a number of areas including: the regulation of early human development, disorders of pregnancy, assisted reproduction programmes, the long term health of children which may be programmed in early development, and the molecular basis of pluripotency in human stem cell populations. We have therefore investigated global gene expression profiles using polyAPCR amplification and microarray technology applied to individual human oocytes and 4-cell and blastocyst stage embryos. In order to explore the basis of any variability in detail, each developmental stage is replicated in triplicate. Our data show that although transcript profiles are highly stage-specific, within each stage they are relatively variable. We describe expression of a number of gene families and pathways including apoptosis, cell cycle and amino acid metabolism, which are variably expressed and may be reflective of embryonic developmental competence. Overall, our data suggest that heterogeneity in human embryo developmental competence is reflected in global transcript profiles, and that the vast majority of existing human embryo gene expression data based on pooled oocytes and embryos need to be reinterpreted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.