ArticlePloS one2013
Role of MELD score and serum creatinine as prognostic tools for the development of acute kidney injury after liver transplantation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review.Frontiers in pharmacology · 2025Pooled it
- Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.Transplantation · 2017Trial
- Methylene Blue Administration Reduces Acute Kidney Injury After Living Donor Liver Transplantation: A Single-Center Retrospective Study.Health science reports · 2026Article
- Acute Kidney Injury Post-Liver Transplant Using Grafts Treated with Hypothermic Machine Perfusion: From Biology to Surgical Aspects.International journal of molecular sciences · 2026Article
- Timing of renal replacement therapy in acute kidney injury after liver transplantation: the clinical value of the NMF standards.Frontiers in medicine · 2026Article
- Perioperative hemoglobin concentrations are associated with acute kidney injury after deceased donor liver transplantation.Frontiers in medicine · 2026Article
- The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting.Viruses · 2024Article
- The impact of acute kidney injury with or without recovery on long-term kidney outcome in patients undergoing living liver transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Article
- Risk factors and prediction of acute kidney injury after liver transplantation: Logistic regression and artificial neural network approaches.World journal of hepatology · 2022Article
- Frequency and Characteristics of Overestimated Renal Function in Japanese Patients with Chronic Liver Disease and Its Relation to Sarcopenia.Nutrients · 2021Article
- Intraoperative hypotension during liver transplant surgery is associated with postoperative acute kidney injury: a historical cohort study.BMC anesthesiology · 2021Article
- Pre- and intraoperative predictors of acute kidney injury after liver transplantation.World journal of clinical cases · 2020Article
- Early Acute Kidney Injury Associated with Liver Transplantation: A Retrospective Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Incidence, Mortality and Predictors of Acute Kidney Injury in Patients with Cirrhosis: A Systematic Review and Meta-analysis.Journal of clinical and translational hepatology · 2020Article
- Renal damage after liver transplantation.Bioscience reports · 2020Article
- Predictive Impact of Modified-Prognostic Nutritional Index for Acute Kidney Injury within 1-week after Living Donor Liver Transplantation.International journal of medical sciences · 2020Article
- Bleeding Complications and Clinical Safety of Endoscopic Retrograde Cholangiopancreatography in Patients with Liver Cirrhosis.Yonsei medical journal · 2019Article
- Incidence and Impact of Acute Kidney Injury after Liver Transplantation: A Meta-Analysis.Journal of clinical medicine · 2019Article
- Correlation Between MELD and UNa/K Ratio in Predicting Renal Dysfunction in Cirrhotic Patients.Journal of translational internal medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the Model for End-Stage Liver Disease (MELD) score in predicting complications, such as Acute Kidney Injury (AKI), after orthotopic liver transplantation (OLT) has yet to be evaluated and serum creatinine may be too heavily weighted in the existing MELD formula, since it has many pitfalls in cirrhotic patients.
methodsRetrospective data of the perioperative period from consecutive adult OLTs performed from January to December 2009 were recorded. Univariate and multivariate analysis were performed to analyze the risk factors for AKI and mortality after OLT.
resultsThere were 114 OLTs performed in the study period, 22 (19,2%) were submitted to dialysis prior OLT and were excluded from the analysis for AKI. The median age was 52 years and 66% were male. Median creatinine value was 0.85mg/dL and MELD was 19. Fifty-two of the 92 patients (56,5%) developed AKI in the first 72 hours after OLT. The only independent risk factor for AKI was calculated MELD and when the components of the MELD score were analyzed, INR had a much stronger impact in predicting AKI then serum creatinine. Overall mortality rate was 32,5% and anesthesia duration was the only variable associated with higher mortality rate.
conclusionsAlthough MELD score seems to have a good performance in predicting AKI after OLT, serum creatinine had no impact on its prediction despite its importance on MELD calculation. Modifying the MELD score, which could include novel AKI biomarkers, may improve its prognostic accuracy and provide a better tool for public health planning.
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