ArticlePloS one2013
The role of osteocytes in targeted bone remodeling: a mathematical model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
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- A review of mathematical modeling of bone remodeling from a systems biology perspective.Frontiers in systems biology · 2024Article
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- Mathematical modeling of the effects of Wnt-10b on bone metabolism.AIChE journal. American Institute of Chemical Engineers · 2022Article
- Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types.eLife · 2022Article
- Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing.PLoS computational biology · 2022Article
- Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats.Journal of traditional and complementary medicine · 2022Article
- Dynamic modeling of bone remodeling, osteolytic metastasis and PK/PD therapy: introducing variable order derivatives as a simplification technique.Journal of mathematical biology · 2021Review
- Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair.Scientific reports · 2021Article
- On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model.Scientific reports · 2021Article
- Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2.International journal of molecular sciences · 2020Review
- Microscopic study of chronic charcot arthropathy foot bones contributes to understanding pathogenesis - A preliminary report.Histology and histopathology · 2020Article
- Modeling Osteocyte Network Formation: Healthy and Cancerous Environments.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- Successful disinfection of femoral head bone graft using high hydrostatic pressure.Cell and tissue banking · 2018Article
- Bone remodeling: A tissue-level process emerging from cell-level molecular algorithms.PloS one · 2018Article
- Role of key players in paradigm shifts of prostate cancer bone metastasis.Cancer management and research · 2018Review
- Bone remodeling as a spatial evolutionary game.Journal of theoretical biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.