ArticlePloS one2013
Thyroid nodule with benign cytology: is clinical follow-up enough?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Comparison of two ablation methods in benign thyroid nodules: Radiofrequency ablation and non-cooled microwave ablation.Journal of clinical imaging science · 2026Article
- Article
- Article
- The McGill Thyroid Nodule Score's (MTNS+) role in the investigation of thyroid nodules with benign ultrasound guided fine needle aspiration biopsies: a retrospective review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2016Article
- Thyroid core needle biopsy: taking stock of the situation.Endocrine · 2015Article
- Fine needle aspiration biopsy of thyroid nodules: cytologic and histopathologic correlation of 1096 patients.International journal of clinical and experimental pathology · 2015Article
- The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration.World journal of surgical oncology · 2014Article
- Determination of the optimal time interval for repeat evaluation after a benign thyroid nodule aspiration.The Journal of clinical endocrinology and metabolism · 2014Article
- What happens in a 5-year follow-up of benign thyroid nodules.Journal of thyroid research · 2014Article
- Imaging-cytology correlation of thyroid nodules with initially benign cytology.International journal of endocrinology · 2014Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this multicenter study, we investigated the management algorithm for thyroid nodules with benign cytology using US features from data collected from 7 institutions. MATERIALS AND
methodsThe institutional review board approved this retrospective study. Data on 700 focal thyroid nodules in 673 consecutive patients were collected from 7 university-affiliated hospitals. This study included nodules that were diagnosed as benign at initial cytologic evaluation and that underwent pathologic or follow-up study. The risk of malignancy was compared according to the US assessments of each institution as well as looking at all the nodules together as a whole.
resultsOf the 700 nodules, 688 (98.3%) were benign and 12 (1.7%) were malignant. If initial cytologic results were benign, the likelihood of the nodule actually being malignant was from 1 to 3%, varying by institution. The likelihood of a cytologically benign nodule with positive US being malignant (4.7%, 8/169) was higher than that of one without positive US (0.8%, 4/531) (P = .002).
conclusionBased on our multicenter study, repeat FNA should be performed in thyroid nodules with initial benign cytology showing suspicious US features in order to decrease the number of false negative cases.
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