Evidence map›Paper›PMID 23717472›Full record

ArticlePloS one2013

Stress and anxiety scores in first and repeat IVF cycles: a pilot study.

Kathy Turner, Margaret F Reynolds-May, Emily M Zitek, Rebecca L Tisdale, Allison B Carlisle, Lynn M Westphal

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
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Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02979990 (Learning From Online Video Education for Controlled Ovarian Stimulation), which is not on this map. Cited by 57 papers, 6 of them syntheses that pooled it.

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57citing papers in PubMed, 6 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02979990 nacompletednot on this mapstarted 2017, after this paper: background citation

Learning From Online Video Education for Controlled Ovarian Stimulation

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2018Enrolled368ConditionsSelf EfficacyArmsInstructional Video, Control Video
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  3. Effects ofFrontiers in reproductive health · 2025
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Kathy TurnerDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America.
Margaret F Reynolds-May
Emily M Zitek
Rebecca L Tisdale
Allison B Carlisle
Lynn M Westphal

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of stress in reproduction, particularly during treatment for infertility, has been of considerable interest; however, few studies have objectively measured stress and anxiety over the course of the IVF cycle or compared the experience of first-time and repeat patients.

methodsThis prospective cohort pilot study enrolled 44 women undergoing IVF at a university-based clinic to complete the State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS) and Infertility Self-Efficacy Scale (ISES) at three time points prior to ovarian stimulation (T1), one day prior to oocyte retrieval (T2), and 5-7 days post embryo transfer (T3).

resultsMean STAI State scores were significantly elevated at all three time points (p<0.01). STAI State and PSS mean values did not change over time and did not differ in first-time vs. repeat patients. Self-efficacy (ISES) scores declined over time, with a greater decline for repeat patients. Of the 36 women who completed a cycle, 15 achieved clinical pregnancy. Using logistic regression modeling, all scores at T2 were correlated with pregnancy outcome with lower scores on the STAI State and PSS and higher scores on the ISES associated with higher pregnancy rates.

conclusionsStress and anxiety levels remained elevated across all cycles. Women with lower stress and anxiety levels on the day prior to oocyte retrieval had a higher pregnancy rate. These results emphasize the need to investigate stress reduction modalities throughout the IVF cycle.

Indexed as

AdultAnxietyFemaleFertilization in VitroHumansInfertility, FemaleOocyte RetrievalPilot ProjectsPregnancyPregnancy RateProspective StudiesStress, PsychologicalSurveys and QuestionnairesTreatment Outcome

Identifiers

PMID23717472
PMCPMC3662783

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.