ArticlePloS one2013
Transthyretin is a key regulator of myoblast differentiation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Tetrameric Transthyretin as a Protective Factor Against Alzheimer's Disease.Molecular neurobiology · 2025Review
- RNA sequencing analysis revealed differentially expressed genes and their functional annotation in porcineFrontiers in veterinary science · 2023Article
- The impact of inflammation and acute phase activation in cancer cachexia.Frontiers in immunology · 2023Review
- Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study.Frontiers in endocrinology · 2021Article
- Article
- Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program.International journal of molecular sciences · 2017Article
- Meeting the meat: delineating the molecular machinery of muscle development.Journal of animal science and technology · 2016Review
- Crucial genes and pathways in chicken germ stem cell differentiation.The Journal of biological chemistry · 2015Article
- Network Analysis for the Identification of Differentially Expressed Hub Genes Using Myogenin Knock-down Muscle Satellite Cells.PloS one · 2015Article
- Expression of Transthyretin during bovine myogenic satellite cell differentiation.In vitro cellular & developmental biology. Animal · 2014Article
- A new era for the Journal of Animal Science and Technology.Journal of animal science and technology · 2014Article
- Article
- Expressed sequence tags for bovine muscle satellite cells, myotube formed-cells and adipocyte-like cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transthyretin (TTR) is a known carrier protein for thyroxine (T4) and retinol-binding protein in the blood that is primarily synthesized in the liver and choroid plexus of the brain. Herein, we report that the TTR gene is expressed in skeletal muscle tissue and up-regulated during myotube formation in C2C12 cells. TTR silencing (TTRkd) significantly reduced myogenin expression and myotube formation, whereas myogenin silencing (MYOGkd) did not have any effect on TTR gene expression. Both TTRkd and MYOGkd led to a decrease in calcium channel related genes including Cav1.1, STIM1 and Orai1. A significant decrease in intracellular T4 uptake during myogenesis was observed in TTRkd cells. Taken together, the results of this study suggest that TTR initiates myoblast differentiation via affecting expression of the genes involved during early stage of myogenesis and the genes related to calcium channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.