ArticlePloS one2013
A new component of the Nasonia sex determining cascade is maternally silenced and regulates transformer expression.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Creating insect neopolyploid lines to study animal polyploid evolution.Evolutionary applications · 2024Article
- Identification of antennal alternative splicing by combining genome and full-length transcriptome analysis inFrontiers in physiology · 2024Article
- SilencingProceedings. Biological sciences · 2022Article
- Evidence of capacitation in the parasitoid wasp,Ecology and evolution · 2020Article
- Genome elimination mediated by gene expression from a selfish chromosome.Science advances · 2020Article
- Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis.PLoS genetics · 2020Article
- Life-history traits of the Whiting polyploid line of the parasitoidEntomologia experimentalis et applicata · 2019Article
- Isolation and Molecular Characterization of the Transformer Gene From Bactrocera cucurbitae (Diptera: Tephritidae).Journal of insect science (Online) · 2017Article
- The study of the transformer gene from Bactrocera dorsalis and B. correcta with putative core promoter regions.BMC genetics · 2016Article
- Article
- Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Population-level consequences of complementary sex determination in a solitary parasitoid.BMC evolutionary biology · 2015Article
- Diploid males support a two-step mechanism of endosymbiont-induced thelytoky in a parasitoid wasp.BMC evolutionary biology · 2015Article
- Review
- The evolutionary dynamics of major regulators for sexual development among Hymenoptera species.Frontiers in genetics · 2015Article
- De novo assembly and transcriptome analysis of the Mediterranean fruit fly Ceratitis capitata early embryos.PloS one · 2014Article
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although sex determination is a universal process in sexually reproducing organisms, sex determination pathways are among the most highly variable genetic systems found in nature. Nevertheless, general principles can be identified among the diversity, like the central role of transformer (tra) in insects. When a functional TRA protein is produced in early embryogenesis, the female sex determining route is activated, while prevention of TRA production leads to male development. In dipterans, male development is achieved by prevention of female-specific splicing of tra mRNA, either mediated by X-chromosome dose or masculinizing factors. In Hymenoptera, which have haplodiploid sex determination, complementary sex determination and maternal imprinting have been identified to regulate timely TRA production. In the parasitoid Nasonia, zygotic transformer (Nvtra) expression and splicing is regulated by a combination of maternal provision of Nvtra mRNA and silencing of Nvtra expression in unfertilized eggs. It is unclear, however, if this silencing is directly on the tra locus or whether it is mediated through maternal silencing of a trans-acting factor. Here we show that in Nasonia, female sex determination is dependent on zygotic activation of Nvtra expression by an as yet unknown factor. This factor, which we propose to term womanizer (wom), is maternally silenced during oogenesis to ensure male development in unfertilized eggs. This finding implicates the upstream recruitment of a novel gene in the Nasonia sex determining cascade and supports the notion that sex determining cascades can rapidly change by adding new components on top of existing regulators.
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