Evidence map›Paper›PMID 23717441›Full record

ArticlePloS one2013

Association of the vaginal microbiota with human papillomavirus infection in a Korean twin cohort.

Jung Eun Lee, Sunghee Lee, Heetae Lee, Yun-Mi Song, Kayoung Lee, Min Ji Han, Joohon Sung, GwangPyo Ko

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05122065 (Defining the Vaginal Microbiome and the Vaginal pH of Menopausal Women With and Without Genitourinary Syndrome and With and Without Hormone Replacement Therapy), which is not on this map. Cited by 222 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
222citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05122065 unknown statusnot on this mapstarted 2021, after this paper: background citation

Defining the Vaginal Microbiome and the Vaginal pH of Menopausal Women With and Without Genitourinary Syndrome and With and Without Hormone Replacement Therapy

TypeobservationalSponsorFemTec Health Inc.Ran2021 to 2022Enrolled432ConditionsMenopause, Hormone Replacement Therapy, Genitourinary Syndrome of Menopause
3 · Its place in the literature

Who cites it

222 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  7. Contribution ofFrontiers in cellular and infection microbiology · 2021
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  17. Sequencing the genome ofMicrobiology resource announcements · 2026
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162 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jung Eun LeeDepartment of Environmental Health and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Republic of Korea.
Sunghee Lee
Heetae Lee
Yun-Mi Song
Kayoung Lee
Min Ji Han
Joohon Sung
GwangPyo Ko

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) is the most important causative agent of cervical cancers worldwide. However, our understanding of how the vaginal microbiota might be associated with HPV infection is limited. In addition, the influence of human genetic and physiological factors on the vaginal microbiota is unclear. Studies on twins and their families provide the ideal settings to investigate the complicated nature of human microbiota. This study investigated the vaginal microbiota of 68 HPV-infected or uninfected female twins and their families using 454-pyrosequencing analysis targeting the variable region (V2-V3) of the bacterial 16S rRNA gene. Analysis of the vaginal microbiota from both premenopausal women and HPV-discordant twins indicated that HPV-positive women had significantly higher microbial diversity with a lower proportion of Lactobacillus spp. than HPV-negative women. Fusobacteria, including Sneathia spp., were identified as a possible microbiological marker associated with HPV infection. The vaginal microbiotas of twin pairs were significantly more similar to each other than to those from unrelated individuals. In addition, there were marked significant differences from those of their mother, possibly due to differences in menopausal status. Postmenopausal women had a lower proportion of Lactobacillus spp. and a significantly higher microbiota diversity. This study indicated that HPV infection was associated with the composition of the vaginal microbiota, which is influenced by multiple host factors such as genetics and menopause. The potential biological markers identified in this study could provide insight into HPV pathogenesis and may represent biological targets for diagnostics.

Indexed as

AdultAgedDNA, BacterialFemaleHumansKoreaMicrobiotaMiddle AgedPapillomaviridaePapillomavirus InfectionsPostmenopauseRNA, Ribosomal, 16SVaginaDNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID23717441
PMCPMC3661536

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.