ArticlePloS one2013
Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- Impact of Horn Traits on Yanhuang Cattle: Association with Production Performance and Genetic Characterization of Candidate Polled Alleles.Animals : an open access journal from MDPI · 2026Article
- Across-breed analyses of genome-wide association studies for stature and mammary gland morphology in cattle reveal pleiotropic effects of the Friesian POLLED haplotype.Genetics, selection, evolution : GSE · 2026Article
- Genome-Wide Association Study and Whole-Genome Resequencing Reveal Key lincRNA and Candidate Gene for Polled Phenotype in Yak.Animals : an open access journal from MDPI · 2026Article
- Forty years in the field: reproductive biotechnologies shaping genetic progress in cattle in France.Animal reproduction · 2026Article
- Recombination events restored the functional horned haplotypes in the offspring of polled parents.Genetics, selection, evolution : GSE · 2025Article
- Exploring skeletal disorders in cattle and sheep: a WGS-based framework for diagnosis and classification.Genetics, selection, evolution : GSE · 2025Article
- The Development of Horns in Bovidae and the Genetic Mechanisms Underpinning This Process.Biology · 2025Review
- Welfare of beef cattle.EFSA journal. European Food Safety Authority · 2025Article
- Multiple cell types guided by neurocytes orchestrate horn bud initiation in dairy goats.Genetics, selection, evolution : GSE · 2025Article
- A bovine model of rhizomelic chondrodysplasia punctata caused by a deep intronic splicing variant in the GNPAT gene.Genetics, selection, evolution : GSE · 2025Article
- Out of Africa: genetic characterization and diversity of Mashona cattle in the United States.Journal of animal science · 2025Article
- Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep.Animals : an open access journal from MDPI · 2024Article
- Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats.BMC genomics · 2024Article
- Gene expression supports a single origin of horns and antlers in hoofed mammals.Communications biology · 2024Article
- Structural variations in livestock genomes and their associations with phenotypic traits: a review.Frontiers in veterinary science · 2024Review
- Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers.Canine medicine and genetics · 2023Article
- Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos.Nature genetics · 2023Article
- Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period.Biology · 2023Article
- In it for the long run: perspectives on exploiting long-read sequencing in livestock for population scale studies of structural variants.Genetics, selection, evolution : GSE · 2023Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
49 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for the existence of at least two different alleles at the Polled locus and identified candidate mutations for each of them. None of these mutations was located in known coding or regulatory regions, thus adding to the complexity of understanding the molecular basis of polledness. We confirm previous results here and exhaustively identify the causative mutation for the Celtic allele (PC) and four candidate mutations for the Friesian allele (PF). We describe a previously unreported eyelash-and-eyelid phenotype associated with regular polledness, and present unique histological and gene expression data on bovine horn bud differentiation in fetuses affected by three different horn defect syndromes, as well as in wild-type controls. We propose the ectopic expression of a lincRNA in PC/p horn buds as a probable cause of horn bud agenesis. In addition, we provide evidence for an involvement of OLIG2, FOXL2 and RXFP2 in horn bud differentiation, and draw a first link between bovine, ovine and caprine Polled loci. Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.