ArticleJournal of ginseng research2013
Protective effects of red ginseng extract against vaginal herpes simplex virus infection.
Article in Journal of ginseng research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Korean red ginseng mitigates pulmonary injury and enhances antiviral immunity in a low-dose pseudo-type SARS-CoV-2 infection model.Journal of ginseng research · 2025Article
- Korean red ginseng extract suppresses food allergy by remodeling the gut microbiota and restoring immune homeostasis in IL4raJournal of ginseng research · 2025Article
- Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng.Journal of ginseng research · 2025Review
- The beneficial potential of ginseng for menopause.Journal of ginseng research · 2024Review
- Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review.Journal of ginseng research · 2023Review
- Antiviral Potential of the GenusJournal of ginseng research · 2023Review
- Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Adaptogenic effects ofJournal of ginseng research · 2021Review
- Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3.Journal of microbiology and biotechnology · 2020Article
- Pharmacological effects of ginseng on infectious diseases.Inflammopharmacology · 2019Review
- Article
- Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients.Journal of ginseng research · 2017Article
- Protective Effect ofFrontiers in immunology · 2017Article
- Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection.Journal of ginseng research · 2016Review
- Prophylactic and therapeutic modulation of innate and adaptive immunity against mucosal infection of herpes simplex virus.Immune network · 2014Review
- Bioactive activities of natural products against herpesvirus infection.Journal of microbiology (Seoul, Korea) · 2013Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have suggested that Korean red ginseng (KRG) extract has various immune modulatory activities both in vivo and in vitro. In this study, we used a mouse model to examine the effects of orally administered KRG extract on immunity against herpes simplex virus (HSV). Balb/c mice were administered with 100, 200, and 400 mg/kg oral doses of KRG extract for 10 d and then vaginally infected with HSV. We found that KRG extract rendered recipients more resistant against HSV vaginal infection and further systemic infection, including decreased clinical severity, increased survival rate, and accelerated viral clearance. Such results appeared to be mediated by increased vaginal IFN-γ secretion. Moreover, increased mRNA expression of IFN-γ, granzyme B, and Fas-ligand was identified in the iliac lymph node and vaginal tracts of KRG extract treated groups (200 and 400 mg/kg). These results suggest that the activities of local natural killer cells were promoted by KRG extract consumption and that KRG may be an attractive immune stimulator for helping hosts overcome HSV infection.
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