ArticleJournal of ginseng research2013
Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury.
Article in Journal of ginseng research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Supplementation with Korean Red Ginseng Improves Current Perception Threshold in Korean Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.Journal of diabetes research · 2020Trial
- The AGE-RAGE-DIAPH1 Axis in Type 2 Diabetes and Metabolic Dysfunction: From Carbonyl Stress to Diabetic Myocardial and Neuronal Injury.International journal of molecular sciences · 2026Review
- The Ginsenoside RgLife (Basel, Switzerland) · 2021Article
- Phytochemicals against anti-diabetic complications: targeting the advanced glycation end product signaling pathway.Archives of pharmacal research · 2021Review
- Pectin-Lyase-Modified Ginseng Extract and Ginsenoside Rd Inhibits High Glucose-Induced ROS Production in Mesangial Cells and Prevents Renal Dysfunction in db/db Mice.Molecules (Basel, Switzerland) · 2021Article
- Article
- Protective Effects of Traditional Polyherbs on Cisplatin-Induced Acute Kidney Injury Cell Model by Inhibiting Oxidative Stress and MAPK Signaling Pathway.Molecules (Basel, Switzerland) · 2020Article
- Article
- A herbal formula, comprisingSaudi journal of biological sciences · 2017Article
- GS-E3D, a new pectin lyase-modified red ginseng extract, inhibited diabetes-related renal dysfunction in streptozotocin-induced diabetic rats.BMC complementary and alternative medicine · 2017Article
- Pectin lyase-modified red ginseng extract exhibits potent anti-glycation effects in vitro and in vivo.Journal of exercise nutrition & biochemistry · 2017Article
- Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease.Journal of ginseng research · 2016Article
- Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells.Journal of ginseng research · 2016Article
- Combination with Red ginseng and Polygoni Multiflori ameliorates highfructose diet induced metabolic syndrome.BMC complementary and alternative medicine · 2016Article
- Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina.Journal of ginseng research · 2016Article
- Ginseng improves cognitive deficit via the RAGE/NF-κB pathway in advanced glycation end product-induced rats.Journal of ginseng research · 2015Article
- Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia.International neurourology journal · 2014Article
- Ginseng total saponin modulates the changes of α-actinin-4 in podocytes induced by diabetic conditions.Journal of ginseng research · 2014Article
- Advanced glycation end products and diabetic complications.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Review
- Safety of red ginseng oil for single oral administration in Sprague-Dawley rats.Journal of ginseng research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of Korean red ginseng (KRG) on diabetic renal damage was investigated using streptozotocin (STZ)-induced diabetic rats. The diabetic rats showed loss of body weight gain, and increases in kidney weight and urine volume, whereas the oral administration of KRG at a dose of 100 or 250 mg/kg of body weight per day for 28 d prevented these diabetes-induced physiological abnormalities. Among the kidney function parameters, elevated plasma levels of urea nitrogen and creatinine in diabetic control rats tended to be lowered in KRG-treated rats. In addition, administration of KRG at a dose of 100 mg/kg body weight in the diabetic rats showed significant decreases in serum glucose and tumor necrosis factor-α (TNF-α), implying that KRG might prevent the pathogenesis of diabetic complications caused by impaired glucose metabolism and oxidative stress. KRG also significantly reduced advanced glycation end product (AGE) formation and secretion from kidney of diabetic rats. Furthermore, KRG decreased the levels of N-(carboxymethyl) lysine and expression of AGE receptor. KRG also reduced the overexpression of cyclooxygenase-2 and inducible nitric oxide synthase in the kidney via deactivation of nuclear factor-kappa B. We also found that KRG prevented STZ-induced destruction of glomerular structure and significantly suppressed high glucose-induced fibronectin production. Taken together, KRG ameliorates abnormalities associated with diabetic nephropathy through suppression of inflammatory pathways activated by TNF-α and AGEs. These findings indicate that KRG has a beneficial effect on pathological conditions associated with diabetic nephropathy.
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