ArticleJournal of ginseng research2013
Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats.
Article in Journal of ginseng research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Investigating the protective properties of Panax ginseng and its constituents against biotoxins and metal toxicity: a mechanistic review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.Environmental science and pollution research international · 2021Review
- Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.Frontiers in pharmacology · 2021Review
- Ginseng attenuates fipronil-induced hepatorenal toxicity via its antioxidant, anti-apoptotic, and anti-inflammatory activities in rats.Environmental science and pollution research international · 2020Article
- Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats.Environmental science and pollution research international · 2020Article
- The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.Environmental science and pollution research international · 2019Article
- Ginseng for Liver Injury: Friend or Foe?Medicines (Basel, Switzerland) · 2016Review
- Protective Effects of Korean Red Ginseng against Alcohol-Induced Fatty Liver in Rats.Molecules (Basel, Switzerland) · 2015Article
- Potential neuroprotective activity of Ginseng in Parkinson's disease: a review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Korean red ginseng is known to regulate the immune system and help the body struggle infection and disease. Cadmium is widely distributed in the environment due to its use in industry. Exposure to cadmium is problematic causing organ dysfunction. This study was conducted to evaluate the protective effect of Korean red ginseng extract (RGE) against cadmium-induced hepatotoxicity in rats. In experiments, animals were orally administrated with RGE (25, 50 mg/kg) for 7 d and then intravenously injected with cadmium (CdCl2, 4 mg/kg) to induce acute hepatotoxicity. Cadmium caused the elevated levels of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase in serum. In contrast, pretreatment with RGE significantly reduced those serum indexes related with liver damage. In histopathological analysis, RGE decreased the centrilobular necrosis around central veins and the peripheral hemorrhage around portal triads. Moreover, RGE restored the deficit in hepatic glutathione level resulting from cadmium treatment. RGE also inhibited the increase in the expression of Bad, a representative apoptosis marker protein, induced by cadmium treatment. Collectively, these results demonstrate that RGE can reduce the cadmium-induced hepatic toxicity, partly via anti-oxidative and anti-apoptotic process.
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