ArticleJournal of ginseng research2012
Ginsenoside Rp1 Exerts Anti-inflammatory Effects via Activation of Dendritic Cells and Regulatory T Cells.
Article in Journal of ginseng research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of Panax species and their bioactive components on allergic airway diseases.Journal of ginseng research · 2024Review
- Potential application of ginseng in sepsis:: Applications of ginseng in sepsis.Journal of ginseng research · 2023Review
- Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells.Journal of ginseng research · 2020Article
- Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism ofBiomolecules · 2020Review
- Effects of ginsenosides on regulatory T cell differentiation.Food science and biotechnology · 2018Article
- Regulatory effects of four ginsenoside monomers in humoral immunity of systemic lupus erythematosus.Experimental and therapeutic medicine · 2018Article
- Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2018Article
- Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis.Acta pharmacologica Sinica · 2014Article
- Red ginseng extract ameliorates autoimmune arthritis via regulation of STAT3 pathway, Th17/Treg balance, and osteoclastogenesis in mice and human.Mediators of inflammation · 2014Article
- Protective effects of red ginseng extract against vaginal herpes simplex virus infection.Journal of ginseng research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ginsenoside Rp1 (G-Rp1) is a saponin derivate that provides anti-metastatic activities through inhibition of the NF-κB pathway. In this study, we examined the effects of G-Rp1 on regulatory T cell (Treg) activation. After treatment of splenocytes with G-Rp1, Tregs exhibited upregulation of IL-10 expression, and along with dendritic cells (DCs), these Tregs showed increased cell number compared to other cell populations. The effect of G-Rp1 on Treg number was augmented in the presence of lipopolysaccharide (LPS), which mimics pathological changes that occur during inflammation. However, depletion of DCs prevented the increase in Treg number in the presence of G-Rp1 and/or LPS. In addition, G-Rp1 promoted the differentiation of the memory types of CD4(+)Foxp3(+)CD62L(low) Tregs rather than the generation of new Tregs. In vivo experiments also demonstrated that Tregs and DCs from mice that were fed G-Rp1 for 7 d and then injected with LPS exhibited increased activation compared with those from mice that were injected with LPS alone. Expression of TGF-β and CTLA4 in Tregs was increased, and upregulation of IL-2 and CD80/ CD86 expression by DCs affected the suppressive function of Tregs through IL-2 receptors and CTLA4. These data demonstrate that G-Rp1 exerts anti-inflammatory effects by activating Tregs in vitro and in vivo.
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Registered trials
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